scholarly journals NEW ORAL ANTICOAGULANTS ARE NOT SUPERIOR TO WARFARIN IN SECONDARY PREVENTION OF STROKE: INSIGHTS FROM A META-ANALYSIS OF RANDOMIZED TRIALS AND INDIRECT TREATMENT COMPARISONS

2013 ◽  
Vol 61 (10) ◽  
pp. E318
Author(s):  
Partha Sardar ◽  
Saurav Chatterjee ◽  
Wen-Chih Wu ◽  
Edgar Lichstein ◽  
Joydeep Ghosh ◽  
...  
Keyword(s):  
Secondary Prevention ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Indirect Treatment ◽  
Treatment Comparisons

Clinical trials with new oral anticoagulants

2013 ◽  
Vol 33 (01) ◽  
pp. 62-70 ◽  
Author(s):  
C. Weiss ◽  
J. Harenberg
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Mixed Treatment ◽  
Total Knee ◽  
Treatment Comparisons ◽  
Mixed Treatment Comparisons

SummaryTo compare the efficacy and safety of the new oral anticoagulants (NOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is a need for an unbiased comparative assessment of the benefits and risks of the NOACs, based on the available trial data. Indirect or mixed treatment comparisons may be an useful tool to overcome these limitations also known as network meta-analysis (NMA).The aim of this paper is to give an overview on published NMAs for dabigatran, rivaroxaban and apixaban, each assessed against warfarin in patients with atrial fibrillation, and against enoxaparin in patients undergoing total knee and total hip replacement surgery, in order to obtain insights into the comparability of the adopted methodological techniques.

New Oral Anticoagulants in Elderly Adults: Evidence from a Meta-Analysis of Randomized Trials

2014 ◽  
Vol 62 (5) ◽  
pp. 857-864 ◽  
Author(s):  
Partha Sardar ◽  
Saurav Chatterjee ◽  
Shobhana Chaudhari ◽  
Gregory Y. H. Lip
Keyword(s):  
Randomized Trials ◽  
Meta Analysis ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Elderly Adults
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