transient ischemic attacks
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Author(s):  
Hiroshi Shima ◽  
Hiroki Taguchi ◽  
Yoshikazu Niwa ◽  
Kuniaki Bandoh ◽  
Yukoh Watanabe ◽  
...  

Vestnik ◽  
2021 ◽  
pp. 91-96
Author(s):  
Г.Ж. Жакенова ◽  
Р.Б. Нуржанова ◽  
К.Б. Сраилова ◽  
Ж.С. Шерияздан ◽  
А.Б. Ташманова ◽  
...  

В данной статье представлен обзор литературы по транзиторным ишемическим атакам: эпидемиология, этиология, патогенез, классификация, основные характеристики с учетом факторов риска, визуализационных признаков МРТ и КТ, клинических проявлений и дифференциальной диагностики данного заболевания на основе современных исследований. This article presents a review of the literature on transient ischemic attacks: epidemiology, etiology, pathogenesis, classification, main characteristics taking into account risk factors, imaging signs of MRI and CT, clinical manifestations and differential diagnosis of this disease based on modern research.


Vestnik ◽  
2021 ◽  
pp. 85-90
Author(s):  
Р.Б. Нуржанова ◽  
Г.Ж. Жакенова ◽  
К.Б. Сраилова ◽  
Ж.С. Шерияздан ◽  
А.Б. Ташманова ◽  
...  

В данной статье представлен обзор литературы по транзиторным ишемическим атакам с учетом современных исследований: диагностика, симптомы и синдромы данного заболевания, дифференциальный диагноз с обоснованием дополнительных методов исследования, лечение, профилактика. This article provides a review of the literature on transient ischemic attacks, taking into account modern research: diagnosis, symptoms and syndromes of this disease, differential diagnosis with substantiation of additional research methods, treatment, prevention.


BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefano Cotti Piccinelli ◽  
Enrico Premi ◽  
Sonia Bonacina ◽  
Nicola Gilberti ◽  
Veronica Vergani ◽  
...  

Abstract Background Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive disorder characterized by elongated and tortuous arteries. Although ATS showed a significant clinical and pathophysiological overlap with other syndromes involving connective tissues, only few cases of cerebrovascular events related to this syndrome have been described so far. Case presentation We report the case of a 33-years-old male diagnosed with ATS since childhood, that experienced three sudden episodes of expressive aphasia and right hemiparesis with spontaneous resolution. He was treated with recombinant tissue plasminogen activator (r-TPA) at a dosage of 0.9 mg/kg with a complete recovery. Brain Magnetic Resonance Imaging (MRI) showed the absence of acute ischemic lesions and the patient was diagnosed with recurrent transient ischemic attacks (TIA). Intracranial and supra-aortic trunks Magnetic Resonance Angiography (MRA) and Angio-CT scan of the thoracic and abdominal aorta showed marked vessel tortuosity without stenosis. To our knowledge, this is the first reported case of an ATS patient with TIA in young age that was treated with intravenous thrombolysis with recombinant plasminogen activator. Conclusion Our report strengthens the relationship between ATS and juvenile cerebrovascular events, suggesting that an extensive study of body vessels in order to detect potential stenoses or occlusions in these cases is needed. The greater predisposition to cerebrovascular events in ATS could benefit from a more aggressive primary and secondary prevention therapy.


2021 ◽  
pp. 92-98
Author(s):  
Yoshinari Nagakane ◽  
Tomoyuki Ohara ◽  
Eijirou Tanaka ◽  
Takehiro Yamada ◽  
Shinji Ashida ◽  
...  

<b><i>Introduction:</i></b> The aim of this study was to test the hypothesis that the attack interval of multiple transient ischemic attacks (TIAs) is correlated with the underlying pathogenesis of ischemia. <b><i>Methods:</i></b> Patients with multiple TIAs, defined as 2 or more motor deficits within 7 days, were studied. The attack interval between the last 2 episodes was classified into 3 groups: 2 episodes within an hour (Hour group), over hours within a day (Day group), and over days within a week (Week group). Patients with a lacunar syndrome, no cortical lesions, and no embolic sources were recognized as having a small vessel disease (SVD) etiology for their multiple events. <b><i>Results:</i></b> Of 312 TIA patients admitted over a 9-year period, 50 (37 males, 13 females, mean 67.6 years) had multiple TIAs. Twelve patients were classified as being within the Hour group, 23 within the Day group, and 15 within the Week group. Lacunar syndromes were observed in 30 (75%, 35%, and 67%), embolic sources were detected in 28 (25%, 65%, and 67%), and a high signal lesion on diffusion-weighted imaging was depicted in 30 (75%, 48%, and 67%) patients (18 cortical, 11 subcortical, and one cerebellar). Patients in the Hour group had a significantly higher prevalence of SVD etiology (75%) than those in the Day and Week groups (30%, <i>p</i> = 0.0165; 27%, <i>p</i> = 0.0213, respectively). Four patients had a subsequent stroke within 7 days. <b><i>Conclusion:</i></b> Attack intervals of multiple TIAs may be correlated with the underlying pathogenesis of ischemia. Two motor deficits within an hour are more likely to suggest a SVD etiology.


2021 ◽  
Vol 4 (9) ◽  
pp. e2126612
Author(s):  
Kori S. Zachrison ◽  
Jessica V. Richard ◽  
Andrew Wilcock ◽  
Jose R. Zubizaretta ◽  
Lee H. Schwamm ◽  
...  

Stroke ◽  
2021 ◽  
Author(s):  
Jacopo Burrello ◽  
Giovanni Bianco ◽  
Alessio Burrello ◽  
Concetta Manno ◽  
Francesco Maulucci ◽  
...  

Background and Purpose: Extracellular vesicles (EVs) are promising biomarkers for cerebral ischemic diseases, but not systematically tested in patients with transient ischemic attacks (TIAs). We aimed at (1) investigating the profile of EV-surface antigens in patients with symptoms suspicious for TIA; (2) developing and validating a predictive model for TIA diagnosis based on a specific EV-surface antigen profile. Methods: We analyzed 40 subjects with symptoms suspicious for TIA and 20 healthy controls from a training cohort. An independent cohort of 28 subjects served as external validation. Patients were stratified according to likelihood of having a real ischemic event using the Precise Diagnostic Score, defined as: unlikely (score 0–1), possible-probable (score 2–3), or very likely (score 4–8). Serum vesicles were quantified by nanoparticle tracking analysis and EV-surface antigen profile characterized by multiplex flow cytometry. Results: EV concentration increased in patients with very likely or possible-probable TIA ( P <0.05) compared with controls. Nanoparticle concentration was directly correlated with the Precise Diagnostic score ( R =0.712; P <0.001). After EV immuno-capturing, CD8, CD2, CD62P, melanoma-associated chondroitin sulfate proteoglycan, CD42a, CD44, CD326, CD142, CD31, and CD14 were identified as discriminants between groups. Receiver operating characteristic curve analysis confirmed a reliable diagnostic performance for each of these markers taken individually and for a compound marker derived from their linear combinations (area under the curve, 0.851). Finally, a random forest model combining the expression levels of selected markers achieved an accuracy of 96% and 78.9% for discriminating patients with a very likely TIA, in the training and external validation cohort, respectively. Conclusions: The EV-surface antigen profile appears to be different in patients with transient symptoms adjudicated to be very likely caused by brain ischemia compared with patients whose symptoms were less likely to due to brain ischemia. We propose an algorithm based on an EV-surface-antigen specific signature that might aid in the recognition of TIA.


Author(s):  
Tursunova M. O ◽  
Abdullaeva M. B ◽  
Kalanov A. B ◽  
Aktamova M.U

Transient-ischemic attacks (TIA) as precursors of cerebral strokes occupy an important place among all forms of cerebrovascular insufficiency. With regard to the epidemiology of transient ischemic attacks (TIA), most countries do not have accurate data. So, in the US, they carry up to 5 million adult citizens per year, with many TIAs remaining undiagnosed. These episodes of sudden and short-term neurological deficit were considered benign and harmless for a long time. Most general practitioners and patients incorrectly or insufficiently understand the nature and significance of TIA, perhaps this can explain the small interest of doctors and the lack of statistical data on this nosological unit. Transient ischemic attacks (TIA) are defined clinically as rapidly occurring focal and less commonly diffuse (cerebral) dysfunctions of the brain that are caused by local ischemia and disappear within one day (Gafurov: 2006). Over the past two decades, many views on TIA have changed significantly; approaches to the diagnosis and treatment of patients have become much more intense and more aggressive. Current knowledge of TIA is of great importance both for the proper organization of patient care and for educational programs among the population, the importance of which cannot be overestimated.


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