scholarly journals ASSOCIATIONS BETWEEN NONALCOHOLIC FATTY LIVER DISEASE AND SUBCLINICAL ATHEROSCLEROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 77 (18) ◽  
pp. 80
Author(s):  
Mark Wong ◽  
Jonathan Yap ◽  
Rehena Sultana ◽  
Khung Keong Yeo
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Subclinical Atherosclerosis ◽  
Nonalcoholic Fatty Liver

scholarly journals Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Enea Bonci ◽  
Claudio Chiesa ◽  
Paolo Versacci ◽  
Caterina Anania ◽  
Lucia Silvestri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Nonalcoholic Fatty Liver ◽  
The Metabolic Syndrome

In the last 20 years, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, primarily as a result of the epidemic of obesity. NAFLD is strongly associated with insulin resistance, glucose intolerance, and dyslipidemia and is currently regarded as the liver manifestation of the metabolic syndrome, a highly atherogenic condition even at a very early age. Patients with NAFLD including pediatric subjects have a higher prevalence of subclinical atherosclerosis, as shown by impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, which are independent of obesity and other established risk factors. More recent work has identified NAFLD as a risk factor not only for premature coronary heart disease and cardiovascular events, but also for early subclinical abnormalities in myocardial structure and function. Thus, we conducted a systematic review and meta-analysis to test the hypothesis that NAFLD is associated with evidence of subclinical cardiac structural and functional abnormalities.

scholarly journals Nonalcoholic fatty liver disease contributes to subclinical atherosclerosis: A systematic review and meta‐analysis

2018 ◽  
Vol 2 (4) ◽  
pp. 376-392 ◽  
Author(s):  
Yao‐Yao Zhou ◽  
Xiao‐Dong Zhou ◽  
Sheng‐Jie Wu ◽  
Dan‐Hong Fan ◽  
Sven Poucke ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Subclinical Atherosclerosis ◽  
Nonalcoholic Fatty Liver

A systematic review and a dose–response meta-analysis of coffee dose and nonalcoholic fatty liver disease

2019 ◽  
Vol 38 (6) ◽  
pp. 2552-2557 ◽  
Author(s):  
Yong-Ping Chen ◽  
Feng-Bin Lu ◽  
Yi-Bing Hu ◽  
Lan-Man Xu ◽  
Ming-Hua Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dose Response ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver

scholarly journals The Association between Periodontitis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

2020 ◽  
Vol 29 (2) ◽  
pp. 211-217
Author(s):  
Karn Wijarnpreecha ◽  
Panadeekarn Panjawatanan ◽  
Wisit Cheungpasitporn ◽  
Frank J Lukens ◽  
Denise M Harnois ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Periodontal Pocket ◽  
Nonalcoholic Fatty Liver ◽  
Unadjusted Analysis

Background and Aims: Recent studies have suggested an association between periodontitis and nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. The current systematic review and meta- analysis was conducted with the aim to comprehensively investigate this possible association by identifying all relevant studies and combining their results together. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through December 2019 to identify all studies that compared the risk of NAFLD among patients with periodontitis to individuals without periodontitis. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of five studies with 27,703 participants fulfilled the eligibility criteria and were included in the meta-analysis. All five studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on the periodontal pocket depth of > 3.5-4 mm. The pooled OR of unadjusted analysis was 1.48 (95%CI: 1.15-1.89; I 2 92%). However, when adjusted results from the primary studies were used, pooled OR decreased to 1.13 and lost its statistical significance (95%CI: 0.95–1.35; I 2 67%). Three studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on a clinical attachment level of ≥ 3 mm. The pooled OR of unadjusted analysis was 1.13 (95%CI: 1.07-1.20; I 2 0%). However, when adjusted results from the primary studied were used, pooled OR decreased to 1.08 and lost its statistical significance (95%CI: 0.94–1.24; I 2 58%). Conclusions: The study found a significant association between periodontitis and NAFLD. However, the association lost its significance when various metabolic parameters were adjusted, suggesting that those metabolic conditions, not periodontitis itself, were predisposing factors for NAFLD.

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