scholarly journals EOSINOPHILIC CARDIOMYOPATHY IN A PATIENT WITH CHRONIC EOSINOPHILIC LEUKEMIA

2021 ◽  
Vol 77 (18) ◽  
pp. 2329
Author(s):  
Ravi A. Thakker ◽  
Krishna Suthar ◽  
Aiham Albaeni ◽  
Ayman Elbadawi ◽  
Nouman Tanveer ◽  
...  
Keyword(s):  
Chronic Eosinophilic Leukemia

scholarly journals Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant

Blood ◽  
2006 ◽  
Vol 108 (4) ◽  
pp. 1374-1376 ◽  
Author(s):  
Els Lierman ◽  
Cedric Folens ◽  
Elizabeth H. Stover ◽  
Nicole Mentens ◽  
Helen Van Miegroet ◽  
...  
Keyword(s):  
Low Dose ◽  
Potent Inhibitor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Low Doses ◽  
Chronic Eosinophilic Leukemia ◽  
Nanomolar Concentration ◽  
Imatinib Resistant ◽  
Factor Receptor Alpha ◽  
Induced Apoptosis

Abstract The FIP1L1-PDGFRA oncogene is a common cause of chronic eosinophilic leukemia (CEL), and encodes an activated tyrosine kinase that is inhibited by imatinib. FIP1L1-PDGFRA–positive patients with CEL respond to low-dose imatinib therapy, but resistance due to acquired T674I mutation has been observed. We report here the identification of sorafenib as a potent inhibitor of the FIP1 like 1–platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) (T674I) mutant. Sorafenib inhibited the proliferation of FIP1L1-PDGFRα and FIP1L1-PDGFRα(T674I)–transformed Ba/F3 cells and induced apoptosis of the EOL-1 cell line at a low nanomolar concentration. Western blot analysis confirmed that these effects were due to a direct effect on FIP1L1-PDGFRα and FIP1L1-PDGFRα(T674I). Sorafenib was recently approved for the treatment of renal cell carcinoma. Our data suggest that low doses of sorafenib could be efficient for the treatment of FIP1L1-PDGFRA–positive CEL and could be used to overcome resistance to imatinib associated with the T674I mutation.

scholarly journals Presentation of a diagnostically challenging case of chronic eosinophilic leukemia with marrow dysplasia and ringed sideroblasts

2020 ◽  
Vol 8 ◽  
pp. 2050313X2095744
Author(s):  
Erica Vormittag-Nocito ◽  
Irum Khan ◽  
Elizabeth Wiley ◽  
Frederick Behm ◽  
Hongyu Ni
Keyword(s):  
Myelodysplastic Syndrome ◽  
Myelodysplastic Syndromes ◽  
Hypereosinophilic Syndrome ◽  
Ringed Sideroblasts ◽  
Chronic Eosinophilic Leukemia ◽  
Not Otherwise Specified

Chronic eosinophilic leukemia, not otherwise specified can be challenging to differentiate from hypereosinophilic syndrome and myelodysplastic syndromes with elevated eosinophilia. We present a diagnostically challenging case of chronic eosinophilic leukemia, not otherwise specified that initially seemed like a myelodysplastic syndrome but progressed to eosinophilic tissue infiltration and overt eosinophilic dyspoiesis. In addition, we discuss the morphologic and molecular findings that can overlap among these entities that made the diagnosis difficult in the case presented.

scholarly journals Sorafenib Induced Complete Cytogenetic and Molecular Response in a Chronic Eosinophilic Leukemia Case with t(12;13) Translocation

2020 ◽  
Author(s):  
Federica Ricci ◽  
Serena Balducci ◽  
Francesca Guerrini ◽  
Susanna Grassi ◽  
Elena Ciabatti ◽  
...  
Keyword(s):  
Molecular Response ◽  
Chronic Eosinophilic Leukemia

scholarly journals Chronic eosinophilic leukemia: a case report and review of literature

2007 ◽  
Vol 23 (3-4) ◽  
pp. 112-115
Author(s):  
Ashutosh Kumar ◽  
Swasti Sinha ◽  
Anil Kumar Tripathi
Keyword(s):  
Case Report ◽  
Review Of Literature ◽  
Chronic Eosinophilic Leukemia

Chronic eosinophilic leukemia with 46,XY,1,der(1;7)(q10;p10) translocation

2004 ◽  
Vol 83 (8) ◽  
Author(s):  
ChiYoung Park ◽  
ChoonHae Chung ◽  
YoungJin Park
Keyword(s):  
Chronic Eosinophilic Leukemia

Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia

2015 ◽  
Vol 99 (11) ◽  
pp. e176-e177 ◽  
Author(s):  
Fanny Fassnacht ◽  
Mathilde Roumier ◽  
Pierre Fouret ◽  
Vincent Levy ◽  
Shaida Varnous ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Endomyocardial Fibrosis ◽  
Chronic Eosinophilic Leukemia

scholarly journals A novel fusion gene involving PDGFRB and GCC2 in a chronic eosinophilic leukemia patient harboring t(2;5)(q37;q31)

2019 ◽  
Vol 7 (4) ◽  
pp. e00591 ◽  
Author(s):  
Noriyoshi Iriyama ◽  
Hiromichi Takahashi ◽  
Hiromu Naruse ◽  
Katsuhiro Miura ◽  
Yoshihito Uchino ◽  
...  
Keyword(s):  
Fusion Gene ◽  
Chronic Eosinophilic Leukemia ◽  
Leukemia Patient
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