hypereosinophilic syndrome
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Author(s):  
Shuichi Tange ◽  
Koji Uchino ◽  
Hirotoshi Kakiwaki ◽  
Hirobumi Suzuki ◽  
Shinzo Yamamoto ◽  
...  

2021 ◽  
Vol 54 (1) ◽  
pp. 11-21
Author(s):  
Xuan Wei ◽  
Xiaofeng Li ◽  
Zuyou Wei ◽  
Hui Zhang ◽  
Jiehua Deng ◽  
...  

2021 ◽  
Vol 37 ◽  
pp. 100915
Author(s):  
Ryohei Ono ◽  
Togo Iwahana ◽  
Hirotoshi Kato ◽  
Sho Okada ◽  
Yoshio Kobayashi

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qian Zhang ◽  
Daoyuan Si ◽  
Zhongfan Zhang ◽  
Wenqi Zhang

Abstract Background Loeffler endocarditis is a relatively rare and potentially life-threatening heart disease. This study aimed to identify the characteristic features of Loeffler endocarditis with intracardiac thrombus on a background of hypereosinophilic syndrome (HES). Case presentation We described a 57-year-old woman with Loeffler endocarditis and intracardiac thrombus initially presenting with neurological symptoms, who had an embolic stroke in the setting of HES. After cardiac magnetic resonance (CMR), corticosteroids and warfarin were administered to control eosinophilia and thrombi, respectively. During a 10-month follow-up, the patient performed relatively well, with no adverse events. We also systematically searched PubMed and Embase for cases of Loeffler endocarditis with intracardiac thrombus published until July 2021. A total of 32 studies were eligible and included in our analysis. Further, 36.4% of recruited patients developed thromboembolic complications, and the mortality rate was relatively high (27.3%). CMR was a powerful noninvasive modality in providing diagnostic and follow-up information in these patients. Steroids were administered in 81.8% of patients, achieving a rapid decrease in the eosinophil count. Also, 69.7% of patients were treated with anticoagulant therapy, and the thrombus was completely resolved in 42.4% of patients. Heart failure and patients not treated with anticoagulation were associated with poor outcomes. Conclusions Cardiac involvement in HES, especially Loeffler endocarditis with intracardiac thrombus, carries a pessimistic prognosis and significant mortality. Early steroids and anticoagulation therapy may be beneficial once a working diagnosis is established. Further studies are needed to provide evidence-based evidence for managing this uncommon manifestation of HES.


2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Mahbuba Sharmin ◽  
Amin Lutful Kabir ◽  
Md. Abdul Aziz ◽  
Sonia Shormin Miah ◽  
Umme Shahera ◽  
...  

World Health Organization defines a rare diagnosis Idiopathic hypereosinophilic syndrome (HES) as a persistent eosinophilia for 6 months and resulting in end-organ dysfunction. Most of the patients present with nonspecific symptoms, while others will present with symptoms of the affected organs, commonly those involving the heart, skin, or nervous system. Gastrointestinal or liver involvement is estimated to affect up to one-third of patients with HES, although patients with clinically significant disease are limited to case reports. This is the first report of a patient presenting with idiopathic HES related hepatitis and achalasia. Hypereosinophilic syndrome has been reported to be associated with hepatic dysfunction; liver histology is mainly characterized by a diffuse eosinophilic inflammatory infiltrate. A 49-yr-old woman, diagnosed as a case of idiopathic hypereosinophilic syndrome with bone marrow and pulmonary eosinophilic infiltrates associated with peripheral eosinophilia,high IgE level  developed features of chronic gatrornteritis, hepatitis, with a significant eosinophil component. She responded well to systemic glucocorticoid  and Imatinib therapy with normalization of liver function tests within a few weeks.


Dermatitis ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kayla Fourzali ◽  
Gil Yosipovitch ◽  
Andrea Maderal

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