scholarly journals Variability of diurnal changes in ambulatory blood pressure and nocturnal dipping status in untreated hypertensive and normotensive subjects

2000 ◽  
Vol 13 (9) ◽  
pp. 1035-1038 ◽  
Author(s):  
G. Manning ◽  
L. Rushton ◽  
R. Donnelly ◽  
M. W. Millar-Craig
2018 ◽  
Vol 03 (01) ◽  
pp. 017-022
Author(s):  
Gopi Kenchi ◽  
Sunisha Gajula ◽  
Malleshwar Dangati

Abstract Aim In recent studies, lack of fall in nocturnal blood pressure (BP) has been presented as an independent predictor of poor prognosis. The aim of this study is to investigate the prognostic value of various variables of BP by 24-hour ambulatory blood pressure (ABP) measurement and sex-related differences after percutaneous transluminal coronary angioplasty (PTCA). Methods This study included 100 patients who underwent PTCA in the authors’ institute from June 2017 to January 2018. They were monitored by 24-hour ABP for 1 day in the hospital. Results One hundred patients were recruited in this study with mean age of 61.64 years, with female-to-male ratio of 0.27:1. All demographic, clinical, and laboratory parameters including the ABP parameters were comparable between females and males, except smoking and alcoholism that were more frequent in males.Out of 100 patients, 41 had nocturnal dipping in BP and 59 did not have nocturnal dipping. In this study, the variables among nondippers, 16 (27.1%) were females, 43 (72.8%) were males, 45 (63.3%) had diabetes mellitus (DM), 46 (75.4%) had hypertension (HTN), mean systolic blood pressure (SBP) was 141.7 ± 13.9 mm Hg, mean diastolic blood pressure (DBP) was 86.34 ± 5.64 mm Hg, mean pulse pressure (PP) was 55.39 ± 9.25 mm Hg, and pulse-wave velocity (PWV) was 6.69 ± 2.22 m/s.In females were more nondippers (27.1%) than dippers (12.1%), which was statistically significant (p = 0.05). Nondippers were more among hypertensive patients (77.9% vs. 36.5%; p = 0.00). Higher mean SBP (p = 0.001), higher mean BP (p = 0.032), and higher mean pulse pressure (p = 0.00) were observed in nondippers.However, age, ejection fraction (EF), presence of DM, coronary artery disease (CAD) severity, type of presentation, and PWV were not different in dipper versus nondippers. Conclusion With comparable clinical, laboratory parameters along with BP parameters between females and males, immediate post-percutaneous coronary intervention (PCI) patients, female PCI patients had more nondippers (p = 0.05). Overall nondippers had higher SBP, mean BP, and PP than dippers. Diabetes, severity of CAD, and type of presentation of CAD (as ACS or CSA) did not influence the nocturnal dipping quality of the BP.


2000 ◽  
Vol 5 (3) ◽  
pp. 169-173 ◽  
Author(s):  
Jean-Michel Mallion ◽  
Sandrine Mouret ◽  
Jean-Philippe Baguet ◽  
Anne Maître ◽  
Jean-Louis Quesada ◽  
...  

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
H Shahab ◽  
H Khan ◽  
M Tufail ◽  
A Artani ◽  
A Almas ◽  
...  

Abstract Funding Acknowledgements Aga Khan University Faculty of Health Sciences Research Committee (#80096) On Behalf PC BP (Post Clinic Blood Pressure) Study Group Background Nocturnal non-dipping increases cardiovascular morbidity and mortality in both hypertensive and normotensive subjects. Ambulatory blood pressure monitoring(ABPM) can identify nocturnal blood pressure(BP) dipping patterns but clinic BP cannot. We previously showed that 15-minute post-clinic BP correlates well with 24- hour ABPM. Purpose We aimed to determine if 15-minute post-clinic BP reading helped to identify patients with nocturnal non-dipping pattern. Methods A cross-sectional study involving 150 participants, as part of the Post Clinic-Ambulatory Blood Pressure(PC-ABP) study, was conducted in cardiology clinics. Participants aged ≥18 years, with hypertension or those referred for its assessment, were included. Pregnant females were excluded. Post-clinic BP was taken 15 minutes after the patient-physician encounter in the clinic using an automated, validated BP device by a research assistant. All the participants were then referred for 24-hour ABPM. Patterns of nocturnal dipping were studied amongst groups of controlled(<140 mmHg) and uncontrolled(≥140mmHg) post-clinic systolic BP(SBP). Fischer exact test was used to determine the difference in dipping patterns amongst the two groups. Results The mean age of participants was 60.3 ± 11.9 years. Of 150 participants, 49% were male and of all, 76% were hypertensive. Mean nighttime SBP(±SD) was 121.9(±18) mmHg(p-value <0.001). Mean nighttime DBP(±SD) was 68.7(± 8.7) mmHg(p < 0.001). Patterns of nocturnal dipping amongst patients with mean post-clinic SBP <140mmHg versus ≥140mmHg has been shown in Table 1. The difference in nocturnal dipping patterns between the two groups was statistically insignificant(p-value 0.071). Pearson correlation coefficient between post-clinic SBP and nighttime SBP for patients with loss of dip was higher (0.64; p < 0.001) whereas it was 0.56(p-value <0.001) for those with preserved dip.  Conclusion Uncontrolled post-clinic BP can help in identifying patients with nocturnal non-dipping. Larger studies can help determine the prognostic value of post-clinic BP amongst patients with nocturnal non-dipping. Nocturnal Dipping Amongst The Two Groups Controlled PC SBP <140mmHg (n = 80) Uncontrolled PC SBP ≥140mmHg (n = 70) Preserved Nocturnal Dipping (10 to 20% nocturnal drop in SBP) 61.2% (n = 49) 47.1% (n = 33) Loss of Dip (>0% to <10% of nocturnal drop in SBP) 33.8% (n = 27) 48.6% (n = 34) Reversed Dip (≤0% drop in SBP) 5% (n = 4) 1.4%(n = 1) Excessive Dip (>20% drop in SBP) 0 2.9% (n = 2) Table 1 shows the patterns of nocturnal dipping amongst patients with controlled (<140mmHg) and uncontrolled (≥140mmHg) 15-minute post-clinic systolic blood pressure (PC SBP).


Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Bae Keun Kim ◽  
Lee Yonggu ◽  
Lim Young-Hyo ◽  
Jinho Shin

Introduction: There have been many reports showing that regular physical exercise can reduce the blood pressure (BP). Thus physical exercise is one of the important components of lifestyle modification of hypertension. It is known that nocturnal BP is an independent factor for the cardiovascular event but there are few studies for the relationship between physical exercise and nocturnal BP. Hypothesis: Hypothesized regular physical exercise reduced nocturnal BP, therefore, we aimed to analyze the relationship between regular physical exercise assessed by a questionnaire (7-day physical activity recall) and nocturnal BP in the general population. Methods: Among 4145 subjects whose data for both clinical data and ambulatory blood pressure monitoring (ABPM) data file from the 5308 Korean ABPM (KorABP) study subjects, 3689 subjects were analyzed. The exclusion criteria was age less than 20 years (n=84), missing data for the questionnaire for physical exercise (n=372). Physical exercise was defined as regular structured exercise which intensity was heavier than the fast walking for 30 minutes. The count was recorded as the number per week. Results: Age was 55.5 ± 14.1 years and female was 45.9 %. Prevalence of hypertension, antihypertensive medication (AHM), diabetes and cardiovascular diseases were 58.9%, 32.5%, 13.0%, and 21.1%, respectively. Daytime and nighttime systolic BP was 138.5 ± 17.2 mmHg and 126.3 ± 18.8 mmHg. When adjusted for age, sex, BMI, and AHM, exercise frequency was independently decreased daytime systolic BP (β = -0.52 mmHg per ex-ercise, p = 0.02). For the nighttime systolic BP further adjusted by daytime systolic BP and sleep quality, ex-ercise frequency was an independent factor (β = -0.26 mmHg per exercise, p = 0.002). The statistical significances were observed even for only for 1 times per week. When further adjusted by smoking, exercise frequency was in-dependent for nocturnal dipping (β = 0.18% per exercise, p = 0.015). Conclusions: Regular physical exercise is independently associated with lower nocturnal BP also lower daytime BP and with increased nocturnal dipping, which was independent of AHM status.


Lupus ◽  
2020 ◽  
Vol 29 (13) ◽  
pp. 1683-1690
Author(s):  
Daniel A Carranza-Leon ◽  
Annette Oeser ◽  
Qiong Wu ◽  
C Michael Stein ◽  
Michelle J Ormseth ◽  
...  

Objectives: Ambulatory blood pressure monitoring measures 24-hour blood pressure, night-time blood pressure, and impaired dipping of nocturnal blood pressure, parameters that better predict cardiovascular risk than standard office blood pressure measurements. Systemic lupus erythematosus is characterized by immune system hyperactivity, elevated cardiovascular risk and high prevalence of hypertension; however, little is known about ambulatory blood pressure in lupus patients and its relationship to immune activation. Methods: We studied 26 patients with lupus and 26 control subjects. We obtained ambulatory 24-hour blood pressure measurements and report plasma concentrations of 77 markers of immune activation using a multiplex immunoassay and assessed their association with blood pressure measurements. Results: Despite similar office blood pressure measurements in patients with lupus and controls, lupus patients had higher 24-hour systolic [median (interquartile range) 129 (113 – 140) vs. 116 (111 – 121) mmHg, p = 0.03] and diastolic blood pressure [80 (69 – 86) vs. 72 (64 – 75) mmHg, p = 0.006] as well as less nocturnal dipping [7.8% (5.1 – 14.2%) vs. 12.0% (8.1 20.0%)] p = 0.03], compared to controls. In patients with lupus, markers of the innate (monocyte chemotactic protein-3) and adaptive immune systems [CUB domain-containing protein-1 and Interleukin-15 receptor subunit-α,] were associated with nocturnal blood pressure measurements and attenuated nocturnal dipping. In conclusion, 24-hour systolic and diastolic blood pressure was higher and nocturnal blood pressure dipping was attenuated in patients with lupus compared to control subjects. Conclusion: In patients with SLE, nocturnal blood pressure and attenuated nocturnal blood pressure dipping were significantly associated with several innate and adaptive immune system biomarkers.


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