Conditional acetyl-CoA carboxylase mutants link fatty acid chain elongation to the structure and function of the nuclear envelope/nuclear pore complex

1997 ◽  
Vol 57 (2) ◽  
pp. 225
Keyword(s):  
Fatty Acid ◽  
Nuclear Envelope ◽  
Nuclear Pore Complex ◽  
Structure And Function ◽  
Chain Elongation ◽  
Nuclear Pore ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Fatty Acid Chain ◽  
And Function

scholarly journals The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function

2006 ◽  
Vol 173 (3) ◽  
pp. 361-371 ◽  
Author(s):  
Alexis S. Madrid ◽  
Joel Mancuso ◽  
W. Zacheus Cande ◽  
Karsten Weis
Keyword(s):  
Electron Microscopy ◽  
Saccharomyces Cerevisiae ◽  
Nuclear Envelope ◽  
Lipid Bilayers ◽  
Nuclear Pore Complex ◽  
Transmembrane Proteins ◽  
Nuclear Pore ◽  
Large Channel ◽  
And Function

The nuclear pore complex (NPC) is a large channel that spans the two lipid bilayers of the nuclear envelope and mediates transport events between the cytoplasm and the nucleus. Only a few NPC components are transmembrane proteins, and the role of these proteins in NPC function and assembly remains poorly understood. We investigate the function of the three integral membrane nucleoporins, which are Ndc1p, Pom152p, and Pom34p, in NPC assembly and transport in Saccharomyces cerevisiae. We find that Ndc1p is important for the correct localization of nuclear transport cargoes and of components of the NPC. However, the role of Ndc1p in NPC assembly is partially redundant with Pom152p, as cells lacking both of these proteins show enhanced NPC disruption. Electron microscopy studies reveal that the absence of Ndc1p and Pom152p results in aberrant pores that have enlarged diameters and lack proteinaceous material, leading to an increased diffusion between the cytoplasm and the nucleus.

Towards a Molecular Understanding of Nuclear Pore Complex Structure and Function

1995 ◽  
pp. 89-92 ◽  
Author(s):  
N. Pante ◽  
R. Bastos ◽  
I. McMorrow ◽  
K. N. Goldie ◽  
B. Burke ◽  
...  
Keyword(s):  
Nuclear Pore Complex ◽  
Complex Structure ◽  
Structure And Function ◽  
Nuclear Pore ◽  
And Function
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