Enantioselective synthesis of (R)- and (S)-2-methyl-4-octanol, the male-produced aggregation pheromone of Curculionidae species

2002 ◽  
Vol 13 (6) ◽  
pp. 621-624 ◽  
Author(s):  
Patricia T. Baraldi ◽  
Paulo H.G. Zarbin ◽  
Paulo C. Vieira ◽  
Arlene G. Corrêa
Keyword(s):  
Aggregation Pheromone ◽  
Enantioselective Synthesis

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

PENELITIAN EKSTRAKSI DAN KARAKTERISASI AGGREGATION PHEROMONE DARI KECOA (Periplaneta americana L)

2008 ◽  
pp. 8-13
Author(s):  
Sri Pudji Rahayu
Keyword(s):  
Aggregation Pheromone ◽  
Periplaneta Americana

Kecoa merupakan serangga yang suka hidup ditempat terlindung, tertutup maupun lipatan-lipatan sehingga susah diberantas, akan tetapi serangga tersebut mempunyai alat komunikasi yang  digunakan untuk memanggil sesamanya untuk berkumpul yang disebut aggregation pheromone. Aggregation pheromone ini diteliti untuk dimanfaatkan sebagai salah satu cara pengendaliannya. Pada penelitian ini aggregation pheromone diteliti dengan mengekstrak kotoran kecoa dengan berbagai macam pelarut dan hasil ekstraknya diuji secara biologi ditunjukkan dengan banyaknya kecoa yang datang dan berkumpul pada ekstrak AP tersebut. Dalam penelitian ini pelarut methanol merupakan pelarut yang paling baik dalam ekstraksi AP yang ditunjukkan adanya 80% kecoa yang datang berkumpul. Dari ekstraksi tersebut setelah dianalisa dengan alat kromatografi gas diperoleh senyawa aktif yang merupakan Aggregation pheromone dari kecoa Periplaneta americana L.  Senyawa tersebut diduga periplanon A dan periplanon B dengan waktu retensi 25,417 menit dan senyawa B dengan waktu retensi 27,007 menit.

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

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