1042 ABTL0812, a Dual Inhibitor of mTOR and Dihydrofolate Reductase With High Oral Efficacy and Safety Margin in Human Lung and Pancreatic Cancer Xenograft in Mice

2012 ◽  
Vol 48 ◽  
pp. S251
Author(s):  
J. Espadaler ◽  
J. Alfón ◽  
J.A. García-Martínez ◽  
C. Domènech ◽  
J.M. Lizcano
Keyword(s):  
Pancreatic Cancer ◽  
Dihydrofolate Reductase ◽  
Human Lung ◽  
Safety Margin ◽  
Efficacy And Safety ◽  
Dual Inhibitor

IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer

2021 ◽  
Vol 522 ◽  
pp. 32-43
Author(s):  
Heng Liang ◽  
Tianqi Li ◽  
Xin Fang ◽  
Zikang Xing ◽  
Shengnan Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dual Inhibitor ◽  
Preclinical Efficacy

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

2000 ◽  
Vol 43 (21) ◽  
pp. 3837-3851 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
John J. McGuire ◽  
Vivian Cody ◽  
Nikolai Galitsky ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
X Ray
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