12: Proffered Paper: The life history of lethal metastatic prostate cancer (The UK prostate cancer working group of the International Cancer Genome Consortium)

2014 ◽  
Vol 50 ◽  
pp. S4
Author(s):  
D.C. Wedge ◽  
G. Gundem ◽  
P. Van Loo ◽  
D. Brewer ◽  
K. Leinonen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Life History ◽  
Working Group ◽  
Metastatic Prostate Cancer ◽  
Cancer Genome ◽  
International Cancer Genome Consortium ◽  
History Of ◽  
Genome Consortium ◽  
The Uk

Sex Hormones and Prostate Cancer

2020 ◽  
Vol 71 (1) ◽  
pp. 33-45 ◽  
Author(s):  
Richard J. Auchus ◽  
Nima Sharifi
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Current Treatment ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
History Of ◽  
Prostate Cancer Research ◽  
Prostate Cancers ◽  
Androgen Independent ◽  
Transition Studies

The prostate is an androgen-dependent organ that develops only in male mammals. Prostate cancer is the most common nonskin malignancy in men and the second leading cause of cancer deaths. Metastatic prostate cancer initially retains its androgen dependence, and androgen-deprivation therapy often leads to disease control; however, the cancer inevitably progresses despite treatment as castration-resistant prostate cancer, the lethal form of the disease. Although it was assumed that the cancer became androgen independent during this transition, studies over the last two decades have shown that these tumors evade treatment via mechanisms that augment acquisition of androgens from circulating precursors, increase sensitivity to androgens and androgen precursors, bypass the androgen receptor, or a combination of these mechanisms. This review summarizes the history of prostate cancer research leading to the contemporary view of androgen dependence for prostate cancers and the current treatment approaches based on this modern paradigm.

The International Cancer Genome Consortium Data Portal

2019 ◽  
Vol 37 (4) ◽  
pp. 367-369 ◽  
Author(s):  
Junjun Zhang ◽  
Rosita Bajari ◽  
Dusan Andric ◽  
Francois Gerthoffert ◽  
Alexandru Lepsa ◽  
...  
Keyword(s):  
Cancer Genome ◽  
International Cancer Genome Consortium ◽  
Genome Consortium ◽  
Data Portal

Abstract LB-308: A novel data safe haven approach to bring analyses to the International Cancer Genome Consortium data

2015 ◽  
Author(s):  
Francisco M. De La Vega ◽  
Ying Wu ◽  
Tal Shmaya ◽  
Thomas Schlumpberger ◽  
James Wiley ◽  
...  
Keyword(s):  
Cancer Genome ◽  
Safe Haven ◽  
International Cancer Genome Consortium ◽  
Genome Consortium
Sign in / Sign up

Export Citation Format

Share Document