Synthesis and aldose reductase inhibitory activities of novel N -nitromethylsulfonanilide derivatives

2000 ◽  
Vol 8 (8) ◽  
pp. 2167-2173 ◽  
Author(s):  
Jun Inoue ◽  
Ying-She Cui ◽  
Osamu Sakai ◽  
Yoshikuni Nakamura ◽  
Hiromi Kogiso ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Activities

Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase

2008 ◽  
Vol 31 (11) ◽  
pp. 1405-1412 ◽  
Author(s):  
Hyun Ah Jung ◽  
Na Young Yoon ◽  
Hyun Ju Bae ◽  
Byung-Sun Min ◽  
Jae Sue Choi
Keyword(s):  
Aldose Reductase ◽  
Coptidis Rhizoma ◽  
Inhibitory Activities

scholarly journals Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor.

1988 ◽  
Vol 36 (4) ◽  
pp. 1404-1414 ◽  
Author(s):  
TAKAYUKI NAMIKI ◽  
YUKIHISA BABA ◽  
YASUTAKA SUZUKI ◽  
MOTOAKI NISHIKAWA ◽  
KOZO SAWADA ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Structural Analogues ◽  
Inhibitory Activities

Synthesis and aldose reductase inhibitory activities of novel thienocinnolinone derivatives

2004 ◽  
Vol 21 (4) ◽  
pp. 545-552 ◽  
Author(s):  
A Pau ◽  
B Asproni ◽  
G Boatto ◽  
G.E Grella ◽  
P De Caprariis ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Activities

scholarly journals Separation and Identification of Antioxidants and Aldose Reductase Inhibitors in Lepechinia meyenii (Walp.) Epling

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2773
Author(s):  
Guanglei Zuo ◽  
Kang-Hoon Je ◽  
Yanymee N. Guillen Quispe ◽  
Kyong-Oh Shin ◽  
Hyun Yong Kim ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Rosmarinic Acid ◽  
High Speed ◽  
Scientific Evidence ◽  
Preparative Hplc ◽  
Meoh Extract ◽  
Traditional Use ◽  
Reductase Inhibitors ◽  
Inhibitory Activities ◽  
Counter Current

We previously reported that Lepechinia meyenii (Walp.) Epling has antioxidant and aldose reductase (AR) inhibitory activities. In this study, L. meyenii was extracted in a 50% MeOH and CH2Cl2/MeOH system. The active extracts of MeOH and 50% MeOH were subjected to fractionation, followed by separation using high-speed counter-current chromatography (HSCCC) and preparative HPLC. Separation and identification revealed the presence of caffeic acid, hesperidin, rosmarinic acid, diosmin, methyl rosmarinate, diosmetin, and butyl rosmarinate. Of these, rosmarinic acid, methyl rosmarinate, and butyl rosmarinate possessed remarkable antioxidant and AR inhibitory activities. The other compounds were less active. In particular, rosmarinic acid is the key contributor to the antioxidant and AR inhibitory activities of L. meyenii; it is rich in the MeOH extract (333.84 mg/g) and 50% MeOH extract (135.41 mg/g) of L. meyenii and is especially abundant in the EtOAc and n-BuOH fractions (373.71–804.07 mg/g) of the MeOH and 50% MeOH extracts. The results clarified the basis of antioxidant and AR inhibitory activity of L. meyenii, adding scientific evidence supporting its traditional use as an anti-diabetic herbal medicine. The HSCCC separation method established in this study can be used for the preparative separation of rosmarinic acid from natural products.

Inhibitory activities of the edible brown alga Laminaria japonica on glucose-mediated protein damage and rat lens aldose reductase

2011 ◽  
Vol 77 (6) ◽  
pp. 1069-1079 ◽  
Author(s):  
You Kyung Son ◽  
Seong Eun Jin ◽  
Hyeung-Rak Kim ◽  
Hee Chul Woo ◽  
Hyun Ah Jung ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Brown Alga ◽  
Laminaria Japonica ◽  
Protein Damage ◽  
Rat Lens Aldose Reductase ◽  
Inhibitory Activities
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