Protein Expression Profiling in High-Risk Breast Cancer Patients Treated with High-Dose or Conventional Dose-Dense Chemotherapy

2008 ◽  
Vol 18 (4) ◽  
pp. 402
Author(s):  
L.A. Carey
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Expression Profiling ◽  
High Dose ◽  
Breast Cancer Patients ◽  
Conventional Dose ◽  
Dose Dense ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

scholarly journals Protein Expression Profiling in High-Risk Breast Cancer Patients Treated with High-Dose or Conventional Dose–Dense Chemotherapy

2007 ◽  
Vol 13 (2) ◽  
pp. 488-497 ◽  
Author(s):  
Raihanatou Diallo-Danebrock ◽  
Evelyn Ting ◽  
Oleg Gluz ◽  
Alexander Herr ◽  
Svjetlana Mohrmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Expression Profiling ◽  
High Dose ◽  
Breast Cancer Patients ◽  
Conventional Dose ◽  
Dose Dense ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Impact of her2/neu status on survival after high-dose chemotherapy in high-risk breast cancer patients

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 905-905
Author(s):  
O. Kuzhan ◽  
A. Ozet ◽  
F. Arpaci ◽  
B. Kurt ◽  
S. Komurcu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

scholarly journals Paclitaxel-containing High-dose Chemotherapy in High-risk Breast Cancer Patients

2000 ◽  
Vol 39 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Hildegard T. Greinix, Werner Linkes
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Identification of high risk breast-cancer patients by gene expression profiling

The Lancet ◽  
2002 ◽  
Vol 359 (9301) ◽  
pp. 131-132 ◽  
Author(s):  
André Ahr ◽  
Thomas Karn ◽  
Christine Solbach ◽  
Tanja Seiter ◽  
Klaus Strebhardt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
High Risk ◽  
Gene Expression Profiling ◽  
Cancer Patients ◽  
Expression Profiling ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Patient selection in high-dose chemotherapy trials: relevance in high-risk breast cancer.

1997 ◽  
Vol 15 (10) ◽  
pp. 3178-3184 ◽  
Author(s):  
R García-Carbonero ◽  
M Hidalgo ◽  
L Paz-Ares ◽  
J Calzas ◽  
H Gómez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
High Dose ◽  
Breast Cancer Patients ◽  
Short Term ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

PURPOSE To evaluate the impact of the selection criteria that are used in current high-dose consolidation chemotherapy (HDCT) trials on the outcome of high-risk breast cancer patients treated with conventional adjuvant chemotherapy. PATIENTS AND METHODS From 1975 to 1995, 265 breast cancer patients at our institution showed involvement of ten or more positive axillary lymph nodes. Of these, 171 received standard adjuvant combination chemotherapy, but not HDCT consolidation, and were the subjects of our study. One hundred twenty-eight patients met the standard selection criteria for HDCT with hematological support (< 60 years, no significant concomitant disease, and no progression during adjuvant treatment), whereas 43 did not. Clinical outcome was analyzed by using disease-free survival (DFS) and overall survival (OS) as endpoints. To provide an assessment of the short-term efficacy of HDCT, we also evaluated the outcome in a cohort of 39 patients from the last 4 years who met the criteria for, and were actually treated with, HDCT after adjuvant chemotherapy. RESULTS With a median follow-up of 4.4 years (range, 0.7 to 17.2 years), 112 of the 171 patients have had a relapse, and 87 have died. The estimated 5-year DFS was 32.3%, and OS was 49.4%. DFS was significantly higher for patients who met the HDCT criteria (36.6% at 5 years) than for those who did not (15.8% at 5 years; P < .05). OS was also significantly more favorable in patients meeting HDCT criteria (55.4% at 5 years) than in patients not meeting HDCT criteria (22.7% at 5 years; P < .01). We performed a multivariate analysis to adjust for other potential prognostic factors and found that meeting the HDCT criteria and having undergone locoregional radiotherapy were the only significant independent predictors for DFS and OS. Finally, we compared the outcome of the 128 patients who met the HDCT criteria and were treated with conventional adjuvant chemotherapy only with that of the 39 patients who met the criteria and who actually underwent HDCT, and we did not observe significant differences in the DFS or OS between these groups. CONCLUSIONS Meeting HDCT inclusion criteria is an independent indicator of favorable prognosis in high-risk breast cancer patients. The selection of patients by these criteria may explain, at least in part, the promising short-term results of nonrandomized adjuvant HDCT trials in high-risk breast cancer.

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