Labeling of octreotide with positron emitters

AbstractIn the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medical care or therapeutic benefit for particular groups of patients. Radionuclides of scandium, namely scandium-43 and scandium-44 (43/44Sc) as positron emitters and scandium-47 (47Sc), beta-radiation emitter, seem to fit ideally into the concept of theranostic pair. This paper aims to review the work on scandium isotopes production, coordination chemistry, radiolabeling, preclinical studies and the very first clinical studies. Finally, standardized procedures for scandium-based radiopharmaceuticals have been proposed as a basis to pave the way for elaboration of the Ph.Eur. monographs for perspective scandium radionuclides.

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EM reconstruction of Dual Isotope PET with staggered injections and prompt gamma positron emitters

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) ◽

10.1109/nssmic.2012.6551850 ◽

2012 ◽

Author(s):

Andriy Andreyev ◽

Arkadiusz Sitek ◽

Anna Celler

Keyword(s):

Prompt Gamma ◽

Dual Isotope ◽

Positron Emitters

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A 4πβ-γ coincidence method for mixed electron-capture/positron emitters: The absolute measurement of 68Ga

The International Journal of Applied Radiation and Isotopes ◽

10.1016/0020-708x(71)90029-9 ◽

1971 ◽

Vol 22 (10) ◽

pp. 615-623 ◽

Cited By ~ 14

Author(s):

D. Smith ◽

A. Williams

Keyword(s):

Electron Capture ◽

Absolute Measurement ◽

Coincidence Method ◽

The Absolute ◽

Positron Emitters

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Sub-millimeter planar imaging with positron emitters: EGS4 code simulation and experimental results

IEEE Transactions on Nuclear Science ◽

10.1109/23.632700 ◽

1997 ◽

Vol 44 (4) ◽

pp. 1499-1502 ◽

Cited By ~ 11

Author(s):

D. Bollini ◽

G. Di Domenico ◽

M. Galli ◽

M. Gambaccini ◽

G. Zavattini

Keyword(s):

Experimental Results ◽

Planar Imaging ◽

Positron Emitters

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Potential Labeling of Monoclonal Antibodies with Positron Emitters

Radiolabeled Monoclonal Antibodies for Imaging and Therapy ◽

10.1007/978-1-4684-5538-0_20 ◽

1988 ◽

pp. 261-267 ◽

Cited By ~ 1

Author(s):

Michael J. Welch ◽

Michael R. Kilbourn

Keyword(s):

Monoclonal Antibodies ◽

Positron Emitters

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Evaluation of self-dose S values for positron emitters in voxel phantoms

Radiation Protection Dosimetry ◽

10.1093/rpd/ncm344 ◽

2007 ◽

Vol 127 (1-4) ◽

pp. 197-200 ◽

Cited By ~ 4

Author(s):

S. Kinase ◽

K. Saito

Keyword(s):

Positron Emitters ◽

Voxel Phantoms

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Srna - Monte Carlo codes for proton transport simulation in combined and voxelized geometries

Nuclear Technology and Radiation Protection ◽

10.2298/ntrp0202027i ◽

2002 ◽

Vol 17 (1-2) ◽

pp. 27-36 ◽

Cited By ~ 8

Author(s):

Radovan Ilic ◽

Darko Lalic ◽

Srboljub Stankovic

Keyword(s):

Monte Carlo ◽

Proton Transport ◽

Transition Probabilities ◽

Three Dimensional ◽

Monte Carlo Techniques ◽

Transport Simulation ◽

Distribution Calculation ◽

Beam Characterization ◽

Positron Emitters ◽

Tomography Data

This paper describes new Monte Carlo codes for proton transport simulations in complex geometrical forms and in materials of different composition. The SRNA codes were developed for three dimensional (3D) dose distribution calculation in proton therapy and dosimetry. The model of these codes is based on the theory of proton multiple scattering and a simple model of compound nucleus decay. The developed package consists of two codes: SRNA-2KG and SRNA-VOX. The first code simulates proton transport in combined geometry that can be described by planes and second order surfaces. The second one uses the voxelized geometry of material zones and is specifically adopted for the application of patient computer tomography data. Transition probabilities for both codes are given by the SRNADAT program. In this paper, we will present the models and algorithms of our programs, as well as the results of the numerical experiments we have carried out applying them, along with the results of proton transport simulation obtained through the PETRA and GEANT programs. The simulation of the proton beam characterization by means of the Multi-Layer Faraday Cup and spatial distribution of positron emitters obtained by our program indicate the imminent application of Monte Carlo techniques in clinical practice.

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