Changes in the content of progesterone receptor isoforms and estrogen receptor alpha in the chick brain during embryonic development

Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: “endometriosis,” “polymorphism,” “ESR1,” “ESR2,” “PROGINS,” “rs9340799,” “rs4986938,” and “rs1042838.” Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis.

Download Full-text

Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2008.10.032 ◽

2009 ◽

Vol 112 (3) ◽

pp. 537-542 ◽

Cited By ~ 91

Author(s):

Vincent Jongen ◽

Justine Briët ◽

Renske de Jong ◽

Klaske ten Hoor ◽

Marike Boezen ◽

...

Keyword(s):

Estrogen Receptor ◽

Endometrial Cancer ◽

Progesterone Receptor ◽

Estrogen Receptor Alpha ◽

Large Cohort ◽

Receptor Alpha ◽

Endometrioid Endometrial Cancer

Download Full-text

Regulation of estrogen receptor-alpha expression in MCF-7 cells by taxol

Journal of Endocrinology ◽

10.1677/joe.0.1800487 ◽

2004 ◽

Vol 180 (3) ◽

pp. 487-496 ◽

Cited By ~ 15

Author(s):

MB Martin ◽

SV Angeloni ◽

P Garcia-Morales ◽

PF Sholler ◽

MD Castro-Galache ◽

...

Keyword(s):

Estrogen Receptor ◽

Progesterone Receptor ◽

Gene Transcription ◽

Estrogen Receptor Alpha ◽

Receptor Protein ◽

Subsequent Increase ◽

Receptor Alpha ◽

Alpha Gene ◽

Er Alpha ◽

Mcf 7

Results presented in this study demonstrate that treatment of MCF-7 cells with taxol resulted in induction of estrogen receptor-alpha (ER alpha) gene transcription with a subsequent increase in ER alpha mRNA; this effect was promoter specific since taxol did not affect total transcription in MCF-7 cells and lacked an effect on transcription of the human acidic ribosomal phosphoprotein protein PO, progesterone receptor, and pS2 genes. In contrast to the increase in transcription of the ER alpha gene, taxol inhibited translation of the ER alpha mRNA. This effect is also transcript specific since taxol did not alter total protein synthesis and did not affect the concentration of progesterone receptor protein in the cell. The overall result of taxol treatment was to decrease the concentration of ER alpha protein in the MCF-7 cells. Evidence is presented that the effects of taxol on ER alpha gene transcription may be mediated through the induction of p53.

Download Full-text