scholarly journals PCN43 COST COMPARISON OF ERLOTINIB VERSUS PEMETREXED FOR THE FIRST-LINE MAINTENANCE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER IN ITALY

2010 ◽  
Vol 13 (7) ◽  
pp. A259 ◽  
Author(s):  
S Ravera ◽  
S Walzer ◽  
J Ray
Lung Cancer ◽  
2012 ◽  
Vol 76 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Mark J.C. Nuijten ◽  
Javier de Castro Carpeño ◽  
Christos Chouaid ◽  
Alain Vergnenègre ◽  
Francesco Grossi ◽  
...  

2012 ◽  
Vol 25 (3) ◽  
pp. 393-395 ◽  
Author(s):  
Stamatis Katsenos ◽  
Melita Nikolopoulou

Gemcitabine, alone or in combination with a platinum-based agent, is indicated for the first-line treatment of patients with locally advanced or metastatic non–small-cell lung cancer. It is generally a well-tolerated drug. Despite its lack of significant toxicity, the most commonly reported side effects include myelosuppression, gastrointestinal disturbances (eg, nausea and vomiting), influenza-like symptoms, skin rash with pruritus, and elevation of liver transaminase enzymes. Peripheral edema has rarely been described as an adverse effect. Herein, we report a patient with advanced non–small-cell lung cancer who experienced severe peripheral edema after gemcitabine administration. Immediate gemcitabine discontinuation and the administration of diuretics resulted in definite regression of peripheral edema.


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