Heterotopic Bone Formation Induced by Bone Morphogenetic Protein Signaling: Fibrodysplasia Ossificans Progressiva

2010 ◽  
Vol 52 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Takenobu Katagiri
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Fibrodysplasia Ossificans Progressiva ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Protein Signaling ◽  
Bone Morphogenetic Protein Signaling ◽  
Morphogenetic Protein

scholarly journals Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century?

2015 ◽  
Vol 51 (2) ◽  
pp. 42-50 ◽  
Author(s):  
Takenobu Katagiri ◽  
Kenji Osawa ◽  
Sho Tsukamoto ◽  
Mai Fujimoto ◽  
Arei Miyamoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Half Century ◽  
Morphogenetic Protein ◽  
History Of

scholarly journals Imaging symptomatic bone morphogenetic protein-2–induced heterotopic bone formation within the spinal canal: case report

2016 ◽  
Vol 24 (5) ◽  
pp. 857-861 ◽  
Author(s):  
Timothy Chryssikos ◽  
Kenneth M. Crandall ◽  
Charles A. Sansur
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Spinal Canal ◽  
Imaging Techniques ◽  
Cauda Equina ◽  
Plain Film ◽  
Bone Morphogenetic Protein 2 ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Morphogenetic Protein

Heterotopic bone formation within the spinal canal is a known complication of bone morphogenetic protein–2 (BMP-2) and presents a clinical and surgical challenge. Imaging modalities are routinely used for operative planning in this setting. Here, the authors present the case of a 59-year-old woman with cauda equina syndrome following intraoperative BMP-2 administration. Plain film myelographic studies showed a region of severe stenosis that was underappreciated on CT myelography due to a heterotopic bony lesion mimicking the dorsal aspect of a circumferentially patent thecal sac. When evaluating spinal stenosis under these circumstances, it is important to carefully consider plain myelographic images in addition to postmyelography CT images as the latter may underestimate the true degree of stenosis due to the potentially similar radiographic appearances of evolving BMP-2–induced heterotopic bone and intrathecal contrast. Alternatively, comparison of sequentially acquired noncontrast CT scans with CT myelographic images may also assist in distinguishing BMP-2–induced heterotopic bony lesions from the thecal sac. Further studies are needed to elucidate the roles of the available imaging techniques in this setting and to characterize the connection between the radiographic and histological appearances of BMP-2–induced heterotopic bone.

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