Phorbol ester (12-O-tetradecanoylphorbol 13-acetate) prevents ornithine decarboxylase inhibition and apoptosis in L1210 leukemic cells exposed to TGF-β1

1996 ◽  
Vol 28 (12) ◽  
pp. 1327-1335 ◽  
Author(s):  
T. Motyl ◽  
Maria Kasterka ◽  
Katarzyna Grzelkowska ◽  
J. Ostrowski ◽  
M. Filipecki ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Phorbol Ester ◽  
Leukemic Cells ◽  
Decarboxylase Inhibition ◽  
Tgf Β1

Ornithine Decarboxylase Inhibition: A Strategy to Combat Various Diseases

2018 ◽  
Vol 18 (12) ◽  
pp. 1008-1021 ◽  
Author(s):  
Rakesh R. Somani ◽  
Priyanshu R. Rai ◽  
Pooja S. Kandpile
Keyword(s):  
Ornithine Decarboxylase ◽  
Decarboxylase Inhibition

Effects of phorbol ester and dexamethasone treatment on histidine decarboxylase and ornithine decarboxylase in basophilic cells

2001 ◽  
Vol 61 (9) ◽  
pp. 1101-1106 ◽  
Author(s):  
Ignacio Fajardo ◽  
Jose L Urdiales ◽  
Miguel A Medina ◽  
Francisca Sanchez-Jimenez
Keyword(s):  
Ornithine Decarboxylase ◽  
Phorbol Ester ◽  
Histidine Decarboxylase ◽  
Dexamethasone Treatment

scholarly journals Heterogeneity of the response of chronic lymphocytic leukemia cells to phorbol ester

Blood ◽  
1982 ◽  
Vol 60 (5) ◽  
pp. 1082-1088 ◽  
Author(s):  
J Okamura ◽  
EW Gelfand ◽  
M Letarte
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Phorbol Ester ◽  
Mixed Lymphocyte Reaction ◽  
Lymphocytic Leukemia ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Phenotypic Markers ◽  
Tumor Promotor ◽  
Bright Surface

Abstract The ability of the tumor promotor 12–0-tetradecanoylphorbol 13-acetate (TPA) to induce differentiation of leukemic cells was studied in 10 cases of chronic lymphocytic leukemia (CLL). An increase in modal volume and an enhancement of the capacity of te leukemic cells to stimulate in mixed lymphocyte reaction (MLR) was seen in the majority of cases. A significant increase in Ia expression was observed upon culture of leukemic cells with TPA in 6 of the 10 cases; 5 of these cases also showed an induction of cytoplasmic IgM production. Correlations between the phenotypic markers of the leukemic cells and their ability to respond to TPA were evaluated. CLL cells with low amounts to surface Ig. a volume less than or equal to 165 fl. and relatively low la expression responded well to TPA. Cells with bright surface Ig. a volume greater than or equal to 178 fl. and elevated amounts of Ia responded poorly to TPA. These results suggest that differences in the response of B leukemic cells to TPA reflect the underlying heterogeneity of the leukemic cells and might be correlated with their stage of maturation.

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