Visual and computational analysis of structure–activity relationships in high-throughput screening data

Computational Analysis ◽

Structure Activity

Topics in Medicinal Chemistry - The Smoothened Receptor in Cancer and Regenerative Medicine ◽

Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design

10.1007/7355_2014_61 ◽

2014 ◽

pp. 43-107 ◽

Cited By ~ 5

Author(s):

Fabrizio Manetti ◽

Maurizio Taddei ◽

Elena Petricci

Keyword(s):

Small Molecule ◽

High Throughput ◽

Mechanism Of Action ◽

Rational Design ◽

Structure Activity

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group

Journal of Medicinal Chemistry ◽

10.1021/jm049640t ◽

2004 ◽

Vol 47 (25) ◽

pp. 6299-6310 ◽

Cited By ~ 190

Author(s):

William Kemnitzer ◽

John Drewe ◽

Songchun Jiang ◽

Hong Zhang ◽

Yan Wang ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Aryl Group ◽

Structure Activity ◽

A Cell

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships ofN-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

Journal of Medicinal Chemistry ◽

10.1021/jm7010657 ◽

2008 ◽

Vol 51 (3) ◽

pp. 417-423 ◽

Cited By ~ 135

Author(s):

William Kemnitzer ◽

John Drewe ◽

Songchun Jiang ◽

Hong Zhang ◽

Candace Crogan-Grundy ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions

10.1016/j.bmcl.2008.09.110 ◽

2008 ◽

Vol 18 (23) ◽

pp. 6259-6264 ◽

Cited By ~ 50

Author(s):

William Kemnitzer ◽

Jared Kuemmerle ◽

Songchun Jiang ◽

Han-Zhong Zhang ◽

Nilantha Sirisoma ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions

10.1016/j.bmcl.2005.07.066 ◽

2005 ◽

Vol 15 (21) ◽

pp. 4745-4751 ◽

Cited By ~ 168

Author(s):

William Kemnitzer ◽

Shailaja Kasibhatla ◽

Songchun Jiang ◽

Hong Zhang ◽

Jianghong Zhao ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell

Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure–activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.12.058 ◽

2012 ◽

Vol 20 (4) ◽

pp. 1442-1460 ◽

Cited By ~ 8

Author(s):

Kihito Hada ◽

Atsushi Suda ◽

Kohsuke Asoh ◽

Takuo Tsukuda ◽

Masami Hasegawa ◽

...

Keyword(s):

Cell Proliferation ◽

Endothelial Cell ◽

High Throughput ◽

Angiogenesis Inhibitors ◽

Biological Evaluation ◽

Endothelial Cell Proliferation ◽

Structure Activity

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.08.002 ◽

2006 ◽

Vol 14 (23) ◽

pp. 7761-7773 ◽

Cited By ~ 25

Author(s):

Nilantha Sirisoma ◽

Shailaja Kasibhatla ◽

Bao Nguyen ◽

Azra Pervin ◽

Yang Wang ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell

Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure–activity relationships of the 2-aryl group

10.1016/j.bmcl.2009.02.074 ◽

2009 ◽

Vol 19 (8) ◽

pp. 2305-2309 ◽

Cited By ~ 12

Author(s):

Nilantha Sirisoma ◽

Azra Pervin ◽

Bao Nguyen ◽

Candace Crogan-Grundy ◽

Shailaja Kasibhatla ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Aryl Group ◽

Structure Activity ◽

A Cell

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure–activity relationships of the carboxamide group

10.1016/j.bmcl.2009.04.009 ◽

2009 ◽

Vol 19 (11) ◽

pp. 3045-3049 ◽

Cited By ~ 17

Author(s):

William Kemnitzer ◽

Nilantha Sirisoma ◽

Bao Nguyen ◽

Songchun Jiang ◽

Shailaja Kasibhatla ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High-Throughput Screening Assay. 3. Structure−Activity Relationships of Fused Rings at the 7,8-Positions

Journal of Medicinal Chemistry ◽

10.1021/jm070216c ◽

2007 ◽

Vol 50 (12) ◽

pp. 2858-2864 ◽

Cited By ~ 125

Author(s):

William Kemnitzer ◽

John Drewe ◽

Songchun Jiang ◽

Hong Zhang ◽

Jianghong Zhao ◽

...

Keyword(s):

High Throughput ◽

Screening Assay ◽

Structure Activity ◽

A Cell