Stage-specific isozymes of ascaris suum complex II: the fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae have the common iron-sulfur subunit

1998 ◽  
Vol 47 ◽  
pp. 339
Author(s):  
H Amino ◽  
H Hirawake ◽  
F. Saruta ◽  
S. Takamiya ◽  
S. Kojima ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Ascaris Suum ◽  
Fumarate Reductase ◽  
Free Living ◽  
Complex Ii ◽  
Iron Sulfur ◽  
The Common

scholarly journals ESR studies on iron-sulfur clusters of complex II in Ascaris suum mitochondria which exhibits strong fumarate reductase activity

FEBS Letters ◽  
1988 ◽  
Vol 242 (1) ◽  
pp. 183-186 ◽  
Author(s):  
Akiko Hata-Tanaka ◽  
Kiyoshi Kita ◽  
Rieko Furushima ◽  
Hiroshi Oya ◽  
Shigeru Itoh
Keyword(s):  
Reductase Activity ◽  
Ascaris Suum ◽  
Fumarate Reductase ◽  
Iron Sulfur Clusters ◽  
Complex Ii ◽  
Iron Sulfur

scholarly journals Cloning of a cDNA encoding the small subunit of cytochrome b558 (cybS) of mitochondrial fumarate reductase (complex II) from adult Ascaris suum

1996 ◽  
Vol 1276 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Fumiko Saruta ◽  
Hiroko Hirawake ◽  
Shinzaburo Takamiya ◽  
Yu-Chang Ma ◽  
Takashi Aoki ◽  
...  
Keyword(s):  
Ascaris Suum ◽  
Small Subunit ◽  
Fumarate Reductase ◽  
Complex Ii ◽  
Cytochrome B558

Electron-transfer complexes of Ascaris suum muscle mitochondria. III. Composition and fumarate reductase activity of complex II

1988 ◽  
Vol 935 (2) ◽  
pp. 130-140 ◽  
Author(s):  
Kiyoshi Kita ◽  
Shinzaburo Takamiya ◽  
Rieko Furushima ◽  
Yu-chang Ma ◽  
Hiroshi Suzuki ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Reductase Activity ◽  
Ascaris Suum ◽  
Fumarate Reductase ◽  
Muscle Mitochondria ◽  
Complex Ii

Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature

2003 ◽  
Vol 284 (5) ◽  
pp. L710-L719 ◽  
Author(s):  
Renate Paddenberg ◽  
Barat Ishaq ◽  
Anna Goldenberg ◽  
Petra Faulhammer ◽  
Frank Rose ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Essential Role ◽  
Electron Flow ◽  
Enzymatic Reaction ◽  
Fumarate Reductase ◽  
Pulmonary Vasculature ◽  
Ros Generation ◽  
Ros Production ◽  
Complex Ii ◽  
Vascular Walls

In the pulmonary vasculature, the mechanisms responsible for oxygen sensing and the initiation of hypoxia-induced vasoconstriction and vascular remodeling are still unclear. Nitric oxide (NO) and reactive oxygen species (ROS) are discussed as early mediators of the hypoxic response. Here, we describe a quantitative analysis of NO- and ROS-producing cells within the vascular walls of murine lung sections cultured at normoxia or hypoxia. Whereas the number of NO-producing cells was not changed by hypoxia, the number of ROS-generating cells was significantly increased. Addition of specific inhibitors revealed that mitochondria were the source of ROS. The participation of the individual mitochondrial complexes differed in normoxic and hypoxic ROS generation. Whereas normoxic ROS production required complexes I and III, hypoxic ROS generation additionally demanded complex II. Histochemically demonstrable succinate dehydrogenase activity of complex II in the arterial wall decreased during hypoxia. Inhibition of the reversed enzymatic reaction, i.e., fumarate reductase, by application of succinate, specifically abolished hypoxic, but not normoxic, ROS generation. Thus complex II plays an essential role in hypoxic ROS production. Presumably, its catalytic activity switches from succinate dehydrogenase to fumarate reductase at reduced oxygen tension, thereby modulating the directionality of the electron flow.

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