Herpes Consensus PCR test: a useful diagnostic approach to the screening of viral diseases of the central nervous system

2002 ◽  
Vol 25 ◽  
pp. 71-78 ◽  
Author(s):  
A Calvario ◽  
A Bozzi ◽  
M Scarasciulli ◽  
C Ventola ◽  
R Seccia ◽  
...  
2005 ◽  
Vol 16 (2) ◽  
pp. 189-212 ◽  
Author(s):  
Claudia Leite ◽  
Alcino Barbosa ◽  
Leandro T Lucato

2011 ◽  
Vol 31 (10) ◽  
pp. 922-925 ◽  
Author(s):  
Luiz F. P Vieira ◽  
Sílvia R.F.G Pereira ◽  
Aline C Galante ◽  
Juliana G Castilho ◽  
Rafael N Oliveira ◽  
...  

Rabies is a neurological disease, but the rabies virus spread to several organs outside the central nervous system (CNS). The rabies virus antigen or RNA has been identified from the salivary glands, the lungs, the kidneys, the heart and the liver. This work aimed to identify the presence of the rabies virus in non-neuronal organs from naturally-infected vampire bats and to study the rabies virus in the salivary glands of healthy vampire bats. Out of the five bats that were positive for rabies in the CNS, by fluorescent antibody test (FAT), viral isolation in N2A cells and reverse transcription - polymerase chain reaction (RT-PCR), 100% (5/5) were positive for rabies in samples of the tongue and the heart, 80% (4/5) in the kidneys, 40% (2/5) in samples of the salivary glands and the lungs, and 20% (1/5) in the liver by RT-PCR test. All the nine bats that were negative for rabies in the CNS, by FAT, viral isolation and RT-PCR were negative for rabies in the salivary glands by RT-PCR test. Possible consequences for rabies epidemiology and pathogenesis are discussed in this work.


1989 ◽  
Vol 19 (4) ◽  
pp. 689-694 ◽  
Author(s):  
Karl Frei ◽  
Ursula V. Malipiero ◽  
Thomas P. Leist ◽  
Rolf M. Zinkernagel ◽  
Martin E. Schwab ◽  
...  

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