scholarly journals Family history of coronary artery disease and prognosis myocardial infarction in the thrombolytic era: Results from the israeli acute myocardial infarction national survey

2000 ◽  
Vol 2 ◽  
pp. 112-112
Author(s):  
D. Harpaz ◽  
S. Gottlieb ◽  
V. Boyko ◽  
Y. Rozenman ◽  
S. Behar
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Family History ◽  
National Survey ◽  
History Of ◽  
Artery Disease

Family History of Coronary Artery Disease and Prognosis after First Acute Myocardial Infarction in a National Survey

Cardiology ◽  
2004 ◽  
Vol 102 (3) ◽  
pp. 140-146 ◽  
Author(s):  
David Harpaz ◽  
Solomon Behar ◽  
Yoseph Rozenman ◽  
Valentina Boyko ◽  
Shmuel Gottlieb
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Family History ◽  
National Survey ◽  
History Of ◽  
Artery Disease

scholarly journals Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Konstantinos Mourouzis ◽  
Gerasimos Siasos ◽  
Evangelos Oikonomou ◽  
Marina Zaromitidou ◽  
Vicky Tsigkou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Family History ◽  
Stable Coronary Artery Disease ◽  
Previous Myocardial Infarction ◽  
History Of ◽  
Artery Disease ◽  
Stable Cad

Abstract Background Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels on indices of arterial wall properties in patients with stable coronary artery disease (CAD). Methods Three hundred seventy-four consecutive patients with stable CAD (mean age 61 ± 11 years, 89% males) were enrolled in this single-center cross-sectional study. Flow-mediated dilation (FMD) was used to assess endothelial function and augmentation index (AIx) of the central aortic pressure was used to assess reflected waves. ELISA was used to determine Lp-PLA2 serum levels. Results After dividing the participants in 3 equal groups based on the tertiles of circulating Lp-PLA2 values, no significant differences were demonstrated between those in the 3rd tertile with Lp-PLA2 values > 138 μg/L, in the 2nd tertile with Lp-PLA2 values between 101 and 138 μg/L and in the 1st tertile (Lp-PLA2 values < 101 μg/L) regarding age, male gender, smoking habits, family history of CAD or history of a previous myocardial infarction, diabetes mellitus, arterial hypertension, hyperlipidemia, duration of CAD and treatment with relevant medication. Importantly, subjects with Lp-PLA2 values in the highest tertile, had significantly reduced FMD values compared to the middle and lower tertile (4.43 ± 2.37% vs. 4.61 ± 1.97% vs. 5.20 ± 2.52% respectively, P = 0.03). Patients in the highest tertile of Lp-PLA2 values had significantly higher AIx values (24.65 ± 8.69% vs. 23.33 ± 9.65%, P = 0.03), in comparison to the lowest tertile, with Lp-PLA2 values < 101 μg/L. A linear regression analysis showed that Lp-PLA2 values > 138 μg/L negatively correlated to FMD [b = − 0.45 (95% CI: − 0.79 – -0.11), P = 0.01] and AIx values [b = 1.81 (95% CI: 0.57–3.05), P < 0.001] independently of cofounders like gender, age, diabetes mellitus, arterial hypertension, dyslipidemia, smoking habits, family history of CAD, history of previous myocardial infarction, serum glucose, circulating lipid levels, duration of CAD, antihypertensive medication, antidiabetic drugs, statin therapy and treatment with β-blockers. Conclusions Elevated Lp-PLA2 levels relate to endothelial dysfunction and arterial stiffness in patients with stable CAD independently from classical risk factors for CAD, statin use, antihypertensive treatment, and duration of the disease.

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