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2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Li He ◽  
Suwen Wang ◽  
Xusheng Ma

Objective. In this study, we explored the influence of single nucleotide polymorphism (SNP) in the noncoding region of intercellular adhesion molecule 1 (ICAM1) gene on the occurrence and metastasis of primary hepatocellular carcinoma (PHC). Methods. Sanger sequencing was used to analyze the genotypes of rs3093032, rs923366, and rs281437 locus in the 3 ′ untranslated region (UTR) of the ICAM1 gene. The level of plasma ICAM1 was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. After adjusting for risk factors such as BMI, smoking, drinking, family history of tumors, and hepatitis B virus test results, the CT genotype at rs3093032 of the ICAM1 gene ( OR = 0.19 , 95% CI: 0.08-0.44, P < 0.01 ), dominance model ( OR = 0.23 , 95% CI: 0.11-0.48, P < 0.01 ), and T allele ( OR = 0.27 , 95% CI: 0.14-0.53, P < 0.01 ) were related to the reduced risk of PHC susceptibility. rs923366 locus CT genotype ( OR = 0.63 , 95% CI: 0.44-0.90, P = 0.01 ), TT genotype ( OR = 0.23 , 95% CI: 0.10-0.53, P < 0.01 ), dominant model ( OR = 0.55 , 95% CI: 0.39-0.77, P < 0.01 ), recessive model ( OR = 0.28 , 95% CI: 0.12-0.62, P < 0.01 ), and T allele ( OR = 0.55 , 95% CI: 0.42-0.73, P < 0.01 ) were related to a reduction in the risk of PHC susceptibility. rs281437 locus CT genotype ( OR = 2.08 , 95% CI: 1.40-3.09, P < 0.01 ), TT genotype ( OR = 5.20 , 95% CI: 2.22-12.17, P < 0.01 ), dominant model ( OR = 2.45 , 95% CI: 1.69-3.54, P < 0.01 ), recessive model ( OR = 4.32 , 95% CI: 1.86-10.06, P < 0.01 ), and T allele ( OR = 2.46 , 95% CI: 1.79-3.38, P < 0.01 ) were significantly related to the increased risk of PHC susceptibility. SNPs at rs3093032, rs923366, and rs281437 of the ICAM1 gene were significantly correlated with TNM stage and tumor metastasis of PHC patients ( P < 0.05 ). Conclusion. SNPs at rs3093032, rs923366, and rs281437 in the 3 ′ UTR region of the ICAM1 gene are related to the occurrence and metastasis of PHC.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiawen Hu ◽  
Qiongjuan Zheng ◽  
Yun Zhang ◽  
Chunyu Liu ◽  
Xuefei Tian ◽  
...  

AbstractThis study aims to know the seeking help behavior of individuals with SZ (Schizophrenia) in Hunan province of China. Individuals (age > 15) with schizophrenia were recruited in the study after a two-stage diagnosis procedure (including questionnaire screening and face-to-face SCID interview by psychiatrists) in Hunan province. A self-designed questionnaire was used to investigate their help-seeking behavior. (1) Of the 367 participants, 68.9% (253/367) sought help; of those, 64.6% (n = 163) pursued professional psychiatric services and 30.8% (n = 78) pursued non-medical options (i.e., relatives, praying to Buddha) as the most common first choices. (2) Family history of mental disorders is significantly related to whether or not the individual with SZ seeks help, and the first choice of help is significantly related to education level. (P < 0.05). (3) Frequent reasons behind not seeking help include fear of stigmatization (72.9%), poor mental health literacy (64.5%), concerns over cost (50.6%), and limited access to medical services (47.0%). About one-third of the individuals do not seek help. Individuals with SZ tend to choose psychiatric hospitals and relatives as their first choice. Among the factors we investigated, family history of mental disorders is the most influential factor associated with help-seeking behavior. Individuals with more education tend to seek professional help first. The primary reasons for not seeking help include fear of stigmatization, lack of awareness about mental illness, concerns over cost, etc.


2021 ◽  
Vol 1 ◽  
pp. 133-139
Author(s):  
Omar Al-Juboori ◽  
Khalid Ibrahim Al-Lehibi

Background: Acromegaly is an uncommon, chronic, debilitating condition characterized by hyperinsulinism, insulin resistance, diabetes and prediabetes. One possibility for managing acromegaly's questionable influence on glucose homeostasis is the somatostatin analogues. Aim: To analyze the frequency and risk factors for impaired glucose homeostasis in acromegaly patients treated with depot long-acting octreotide (octreotide LAR), as well as the relationship between risk and treatment duration. Methods: The study included 52 Iraqi adults with acromegaly receiving octreotide LAR. Demographic, anthropometric, and clinical data were collected, as well as the duration of Octreotide LAR administration. Growth hormone, IGF-1, and adenoma size were reported retrospectively from patient data. The glycemic state was assessed and classified as DM, prediabetes, or normal. Results: The prevalence of DM was 39% and prediabetes was 40%, with the exception of being male, which was substantially related with prediabetes. DM and octreotide LAR use had a non-significant correlation. However, octreotide use altered 13% of patients from normal glycemic to prediabetes, with no correlation to treatment duration. Other than hypertension and a family history of diabetes, no other variables were found to be significant. Conclusion: Acromegaly patients have abnormal glucose metabolism, which is associated with prediabetes owing to octreotide LAR medication. Hypertension and family history of diabetes are risk factors.


Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Ibraheem F. Alshiddi ◽  
Syed Rashid Habib ◽  
Kamran Sattar ◽  
Abdullah Alshahrani ◽  
Rya S. Almufleh ◽  
...  

OBJECTIVE: The aim of this study was to investigate the prevalence of metabolic syndrome (MS) among dentists in Riyadh, Saudi Arabia. The study also explored the causes of occupational stress among the participating dentists. MATERIALS & METHODS: The participants included a conveniently selected sample of dentists (N = 126; Males = 65; Females = 61). The participants’ anthropometric measurements/blood sample analysis were carried out and they completed a self-administered questionnaire. Data analysis included demographics, gender/age wise comparison using SPSS (p <  0.05). For the diagnosis of MS, updated criteria of the National Cholesterol Education Program was applied. RESULTS: Participants diagnosed with MS were 13 (10.3%), Males = 11(8.7%) and Females = 2(1.5%). Physical activity of 6 (15.8%) with MS was only 0–2 hours/week. 9 (14.5%) participants with MS declared positive family history for MS. The average systolic (117.55±11.33) and diastolic blood pressure (71.9±9.34) of the participants was found to be normal with no gender wise statistical difference. No gender wise statistical differences (p >  0.05) were observed for cholesterol, triglycerides and HDL. However, significant difference (p = 0.00) was found for the fasting glucose level (Males = 5.69±1.49; Females = 4.94±0.42). Overall mean scoring (3.00±1.11) for the stress showed that the participants fall into the average/moderate level of stress category (Males = 3.16±1.02; Females = 2.83±1.08). Almost two third (68.26%) of the participant’s responded that they were under some kind of stress. CONCLUSIONS: MS was found to be less frequent among the dentists working in the city of Riyadh. Overall, the dentists were under moderate level of occupational stress, with male dentists being more prone to work related stress.


Author(s):  
Laura A. Arnés ◽  
Silvana Abal

This article analyses 98 segundos sin sombra (2014) by Giovanna Rivero, one of the most representative writers of Bolivian “new narrative.” 98 segundos problematizes the gendered matrices of culture, foregrounding young and feminized fictional subjectivities that exercise disobedience as a mode of self-determination. Through the re-appropriation of family history and imposed affects, the protagonists build alternative ways of existence by practising detours and deviations, expressing what Julia Kristeva terms “revolt.” These “revolts” establish a conflictive link with the past and, at the same time, emphasize uncertainty about the future. They enable the possibility of distancing oneself from one’s own memory, giving rise to new figures of temporality and calling into question the idea of “civilization.” --- Este artículo analiza 98 segundos sin sombra (2014) de Giovanna Rivero, una de las escritoras más representativas de la “nueva narrativa” boliviana. 98 segundos problematiza las matrices generizadas de la cultura, al construir subjetividades ficcionales jóvenes y feminizadas que ejercen la desobediencia como modo de autodeterminación. En la reapropiación del pasado familiar y de los afectos impuestos, las protagonistas operan sobre ellos desvíos que les permite construir modos de existencia alternativos, “re-vueltas” (Kristeva, 1998) que instalan un vínculo conflictivo con el pasado al tiempo que alojan la incertidumbre sobre el futuro; que habilitan la posibilidad de distanciarse de la propia memoria y dan lugar a nuevas figuras de la temporalidad, llegando a poner en crisis la misma idea de “civilización.”


Author(s):  
Sule Olgun ◽  
Berna Dizer

Abstract Background Breast cancer risk increases by 80% in the presence of BRCA1 and BRCA2 gene mutations in the same family. In particular, a woman whose sister or mother has breast cancer has a 2- to 5-fold higher risk of developing breast cancer compared with other women. For this reason, recommendations should have been made regarding breast cancer prevention and/or early detection for women with first-degree family history of breast cancer. Aim The aim of this study was to evaluate the effect of health education, which was provided to first-degree female relatives of breast cancer patients, on their health beliefs and behaviors. Study Design and Methods The study sample included 50 women with a first-degree relative being treated for breast cancer in the chemotherapy and radiotherapy unit of a university hospital. A one-group pretest-posttest design was used. The pretest consisted of the health belief model scale and a questionnaire regarding the women’s sociodemographic information and breast cancer screening behaviors. After the pretest, the patients received health education regarding breast cancer risk factors and screening methods. The posttest was conducted 3 weeks after the education using the same assessment tools. Results After education, there were statistically significant increases in rates of practicing breast self-examination, having clinical breast examinations, and undergoing breast ultrasound/mammography compared with pretest results. Conclusions Health workers should possess knowledge and experience about breast cancer which will enable them to effectively undertake an educational role, especially for high-risk groups such as women with first-degree family history of breast cancer.


Author(s):  
Giovanna Masala ◽  
Domenico Palli ◽  
Ilaria Ermini ◽  
Daniela Occhini ◽  
Luigi Facchini ◽  
...  

Background: Diet and physical activity (PA) can modulate sporadic and possibly familial breast cancer (BC) risk. The DAMA25 study is a single-arm 12-month intervention aimed to modify dietary and PA habits in healthy young Italian women with a positive BC family history, categorized as having intermediate or high genetic risk according to NICE (National Institute for Health and Cancer Excellence) guidelines. Methods: Participants, aged 25–49 years, were asked to adopt a diet mainly based on plant-based foods and to increase moderate daily activities combined with 1 h/week of more intense activity. Cooking lessons, collective walks, educational sessions, brochures, booklets and online materials were implemented. Dietary, PA habits and anthropometry were collected at baseline and at the end of the intervention. Changes on dietary, lifestyle habits and anthropometry were evaluated by GLM adjusted for weight reduction counselling aimed to participant with a BMI ≥ 25, age and baseline values of each variable. Results: Out of 237 eligible women 107 (45.2%) agreed to participate and among them 98 (91.6%) completed the intervention. The adherence rate of the intervention was 77.8%. We observed a reduction in red and processed meat (p < 0.0001) and cakes consumption (p < 0.0001). Consumption of whole grain bread (p < 0.001), leafy vegetables (p = 0.01) and olive oil (p = 0.04) increased. We observed an increase in moderate (p < 0.0001) and more intense (p < 0.0001) recreational activities, an average 1.4 kg weight loss (p = 0.005), a reduction of waist circumference (p < 0.001) and fat mass (p = 0.015). Conclusions: The DAMA25 study shows that it is feasible an intervention to improve in the short-term dietary and PA habits and anthropometry in women with high BC familial risk.


2021 ◽  
pp. 749-754
Author(s):  
Fumihito Yoshii ◽  
Koji Aono ◽  
Ryuya Kumazawa ◽  
Wakoh Takahashi

We report a 34-year-old female PARK2 patient presenting with dopa-responsive dystonia (DRD). She noticed difficulty in raising her foot while walking at the age of 24. Her lower limb symptoms were identified as dystonia later, and she was started on Menesit, which resulted in improvement of her symptoms. She was diagnosed as DRD and has been on continuous treatment since then. The specific binding ratio (SBR) of <sup>123</sup>I FP-CIT SPECT was significantly lower than those of controls of the same age, but <sup>123</sup>I-meta-iodobenzylguanidine myocardial scintigraphy showed a normal heart to mediastinum ratio. The Montreal Cognitive Assessment, Japanese version, was normal for her age. DRD is an inherited dystonia that typically begins during childhood and may be caused by mutations of the GCH1 (GTP cyclohydrolase), SPR (sepiapterin reductase), or TH (tyrosine hydroxylase) genes. Our patient was diagnosed as PARK2, known as autosomal-recessive juvenile Parkinson’s disease, based on genetic analysis. Although there was no family history of the disease, the decrease in SBR of <sup>123</sup>I FP-CIT SPECT enabled us to diagnose PARK2 and to differentiate this from DRD due to other genetic disorders.


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