scholarly journals Endocochlear Potential and Potassium Concentration Recording in Minipig Cochlea

2012 ◽  
Vol 7 (2) ◽  
pp. 103-105
Author(s):  
Weiwei GUO ◽  
Chen Lei ◽  
Li Dengke ◽  
Sun Wei ◽  
Yang Shiming
Keyword(s):  
Potassium Concentration ◽  
Endocochlear Potential

Endocochlear potential and potassium concentration in endolymph and perilymph of the chinchilla

1980 ◽  
Vol 229 (2) ◽  
pp. 149-153 ◽  
Author(s):  
Tetsuo Morizono ◽  
Leonard P. Rybak ◽  
Steven Asp
Keyword(s):  
Potassium Concentration ◽  
Endocochlear Potential

Effect of vestibular labyrinth destruction on endocochlear potential and potassium concentration of the cochlea

2010 ◽  
Vol 265 (1-2) ◽  
pp. 90-95 ◽  
Author(s):  
Ryoukichi Ikeda ◽  
Kazuhiro Nakaya ◽  
Muneharu Yamazaki ◽  
Takeshi Oshima ◽  
Tetsuaki Kawase ◽  
...  
Keyword(s):  
Potassium Concentration ◽  
Endocochlear Potential ◽  
Vestibular Labyrinth

An L1 retrotransposon insertion–induced deafness mouse model for studying the development and function of the cochlear stria vascularis

2021 ◽  
Vol 118 (40) ◽  
pp. e2107933118
Author(s):  
Chenmeng Song ◽  
Jie Li ◽  
Shuang Liu ◽  
Hanqing Hou ◽  
Tong Zhu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Potassium Concentration ◽  
Stria Vascularis ◽  
Endocochlear Potential ◽  
Mutant Mice ◽  
Chromosome 11 ◽  
Fluid Homeostasis ◽  
Retrotransposon Insertion ◽  
And Function ◽  
L1 Retrotransposon

Dysregulation of ion and potential homeostasis in the scala media is the most prevalent cause of hearing loss in mammals. However, it is not well understood how the development and function of the stria vascularis regulates this fluid homeostasis in the scala media. From a mouse genetic screen, we characterize a mouse line, named 299, that displays profound hearing impairment. Histology suggests that 299 mutant mice carry a severe, congenital structural defect of the stria vascularis. The in vivo recording of 299 mice using double-barreled electrodes shows that endocochlear potential is abolished and potassium concentration is reduced to ∼20 mM in the scala media, a stark contrast to the +80 mV endocochlear potential and the 150 mM potassium concentration present in healthy control mice. Genomic analysis revealed a roughly 7-kb-long, interspersed nuclear element (LINE-1 or L1) retrotransposon insertion on chromosome 11. Strikingly, the deletion of this L1 retrotransposon insertion from chromosome 11 restored the hearing of 299 mutant mice. In summary, we characterize a mouse model that enables the study of stria vascularis development and fluid homeostasis in the scala media.

Influence of Potassium Deprivation and Adrenalectomy on Potassium Concentration of the Myocardium

1955 ◽  
Vol 181 (3) ◽  
pp. 550-552 ◽  
Author(s):  
Shirley St. George ◽  
S. Charles Freed ◽  
Ray H. Rosenman ◽  
Sara Winderman
Keyword(s):  
Potassium Concentration ◽  
Potassium Deprivation

scholarly journals Correcting hypokalaemia in a paediatric patient with Bartter syndrome through oral dose of potassium chloride intravenous solution

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110197
Author(s):  
Salman Alasfour ◽  
Haya S Alfailakawi ◽  
Yousif A Shamsaldeen
Keyword(s):  
Paediatric Patient ◽  
Potassium Chloride ◽  
Serum Potassium ◽  
Nasogastric Tube ◽  
Potassium Concentration ◽  
Oral Route ◽  
Bartter Syndrome ◽  
Intravenous Route ◽  
Serum Potassium Concentration ◽  
Main Challenge

Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalaemia. Hypokalaemia is defined as low serum potassium concentration ˂3.5 mmol/L, which may lead to arrhythmia and death if left untreated. The aim of this case report was to normalize serum potassium concentration without the need for intravenous intervention. A 5-month-old male of 2.7 kg body weight diagnosed with Bartter syndrome was admitted to the general paediatric ward with acute severe hypokalaemia and urinary tract infection. The main challenge was the inability to administer drugs through intravenous route due to compromised body size. Therefore, we shifted the route of administration to the nasogastric tube/oral route. A total of 2 mL of concentrated intravenous potassium chloride (4 mEq potassium) were dissolved in distilled water and administered through nasogastric tube. Serum potassium concentration was rapidly normalized, which culminated in patient discharge. In conclusion, shifting drug administration from intravenous to oral route in a paediatric patient with Bartter syndrome includes numerous advantages such as patient convenience, minimized risk of cannula-induced infection, and reduced nurse workload.

scholarly journals Association between Blood Potassium Level and Recovery of Postoperative Gastrointestinal Motility during Continuous Renal Replacement Therapy in Patient Undergoing Open Abdominal Surgery

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yi Yang ◽  
Jingjuan Yang ◽  
Xiner Yao ◽  
Yu Cui ◽  
Xiabing Lang ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Gastrointestinal Motility ◽  
Potassium Level ◽  
Potassium Concentration ◽  
Binary Logistic Regression ◽  
Plasma Potassium ◽  
Postoperative Recovery ◽  
Binary Logistic Regression Model ◽  
Open Abdominal Surgery ◽  
Blood Potassium

Background. The aim of this study was to identify the blood potassium level beneficial to the postoperative recovery of gastrointestinal motility during continuous renal replacement therapy (CRRT) in patient undergoing open abdominal surgery. Materials and Methods. 538 critically ill patients after open abdominal surgery and receiving CRRT were retrospectively recruited as the study cohort. Demographic and clinical data were recorded along with an evaluation of the postoperative gastrointestinal motility. Results. Correlation analysis was used to assess the correlation coefficient, and then the variables with correlation coefficient value less than 0.5 were included in the binary logistic regression model. Binary logistic regression model indicated that the postoperative blood potassium level was independently associated with the recovery of gastrointestinal motility (OR=0.109, 95% CI= 0.063 to 0.190, p<0.001). Based on the normal range of blood potassium level, we selected the cut-off point of blood potassium level via Weight of Evidence analysis, which was 4.00 mmol/L. Compared with the patients with insufficient blood potassium levels (plasma potassium concentration < 4.00 mmol/L), those with sufficient blood potassium levels (plasma potassium concentration≥ 4.00 mmol/L) conferred an increase in the rate of 4-day postoperative recovery of gastrointestinal motility (OR= 4.425, 95% CI = 2.933 to 6.667, p<0.001). Conclusions. Maintaining the blood potassium concentrations at a relatively high level of the normal blood potassium range during CRRT would be beneficial to postoperative recovery of gastrointestinal motility.

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