Chapter 11 Total synthesis and mechanism of action studies on the antitumor alkaloid, (-)-agelastatin a

2005 ◽  
pp. 352-394 ◽  
Author(s):  
Karl J. Hale ◽  
Mathias M. Domostoj ◽  
Mohamed El-Tanani ◽  
F. Charles Campbell ◽  
Charlene K. Mason
Keyword(s):  
Total Synthesis ◽  
Mechanism Of Action ◽  
Agelastatin A

scholarly journals Total synthesis of griseusins and elucidation of the griseusin mechanism of action

2019 ◽  
Vol 10 (32) ◽  
pp. 7641-7648 ◽  
Author(s):  
Yinan Zhang ◽  
Qing Ye ◽  
Larissa V. Ponomareva ◽  
Yanan Cao ◽  
Yang Liu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Mechanism Of Action ◽  
Tail Regeneration ◽  
Sar Studies

An efficient divergent synthesis of griseusins enabled SAR studies, mechanistic elucidation and evaluation in an axolotl tail regeneration model.

scholarly journals Enantiospecific Formal Total Synthesis of the Tumor and GSK-3β Inhibiting Alkaloid, (-)-Agelastatin A.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Karl J. Hale ◽  
Mathias M. Domostoj ◽  
Derek A. Tocher ◽  
Ed Irving ◽  
Feodor Scheinmann
Keyword(s):  
Total Synthesis ◽  
Agelastatin A ◽  
Gsk 3Β

Total Synthesis of (−)-Agelastatin A: The Application of a Sequential Sigmatropic Rearrangement

2009 ◽  
Vol 11 (12) ◽  
pp. 2687-2690 ◽  
Author(s):  
Naoto Hama ◽  
Tomoki Matsuda ◽  
Takaaki Sato ◽  
Noritaka Chida
Keyword(s):  
Total Synthesis ◽  
Sigmatropic Rearrangement ◽  
Agelastatin A

scholarly journals Bioinspired Total Synthesis of Agelastatin A

2012 ◽  
Vol 51 (28) ◽  
pp. 6870-6873 ◽  
Author(s):  
Jeremy Chris P. Reyes ◽  
Daniel Romo
Keyword(s):  
Total Synthesis ◽  
Agelastatin A

ChemInform Abstract: Studies on Total Synthesis of the Cytotoxic Marine Alkaloid Agelastatin A.

ChemInform ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. no-no
Author(s):  
Glen T. Anderson ◽  
Charles E. Chase ◽  
Yung-hyo Koh ◽  
Didier Stien ◽  
Steven M. Weinreb ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Agelastatin A ◽  
Marine Alkaloid

Total Synthesis of the Antitumor Marine Sponge Alkaloid Agelastatin A

1999 ◽  
Vol 121 (41) ◽  
pp. 9574-9579 ◽  
Author(s):  
Didier Stien ◽  
Glen T. Anderson ◽  
Charles E. Chase ◽  
Yung-hyo Koh ◽  
Steven M. Weinreb
Keyword(s):  
Total Synthesis ◽  
Marine Sponge ◽  
Agelastatin A

Total synthesis of (−)-agelastatin A: an SH2′ radical azidation strategy

2018 ◽  
Vol 54 (71) ◽  
pp. 9893-9896 ◽  
Author(s):  
Izuru Tsuchimochi ◽  
Yuta Kitamura ◽  
Hiroshi Aoyama ◽  
Shuji Akai ◽  
Keiyo Nakai ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Synthetic Approach ◽  
Enol Ether ◽  
Agelastatin A ◽  
Silyl Enol Ether ◽  
Strategic Implementation ◽  
Allylic Bromide

A new synthetic approach to (−)-agelastatin A has been established through the strategic implementation of brominative olefin transposition of a silyl enol ether and subsequent SH2′ radical azidation of the resultant allylic bromide.

Enantiospecific Formal Total Synthesis of the Tumor and GSK-3β Inhibiting Alkaloid, (−)-Agelastatin A

2003 ◽  
Vol 5 (16) ◽  
pp. 2927-2930 ◽  
Author(s):  
Karl J. Hale ◽  
Mathias M. Domostoj ◽  
Derek A. Tocher ◽  
Ed Irving ◽  
Feodor Scheinmann
Keyword(s):  
Total Synthesis ◽  
Agelastatin A ◽  
Gsk 3Β
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