This chapter reviews applications of Benford's law to uncover fraud in macroeconomic data, forecasts, and econometric regression results, as Benford's law provides tools for checking reliability and detecting fraud in science and academia. Scientific misconduct appears in various forms: fabrication, falsification, and plagiarism. Replication is considered the prime strategy against scientific misconduct, but it is seldom performed in empirical economics. Regardless, the potential of Benford's law to enhance the efficiency of replication as a strategy against fraud in published research is discussed in this chapter. In addition, the chapter remarks that routine applications of Benford tests could uncover data anomalies and provide valuable hints of irregularities in empirical economics research.