scholarly journals Sensorineural hearing loss in Wegener's granulomatosis—cytotoxic chemotherapy

1989 ◽  
Vol 103 (12) ◽  
pp. 1234-1234
Author(s):  
G. E. Murty ◽  
J. P. Birchall
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Cytotoxic Chemotherapy ◽  
Sensorineural Hearing

Otologic Manifestations of Wegener's Granulomatosis

1980 ◽  
Vol 88 (5) ◽  
pp. 586-593 ◽  
Author(s):  
Thomas V. McCaffrey ◽  
Thomas J. McDonald ◽  
George W. Facer ◽  
Richard A. DeRemee
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Tympanic Membrane ◽  
Middle Ear ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Tympanic Membrane Perforation ◽  
Sensorineural Hearing ◽  
Suppurative Otitis Media ◽  
Membrane Perforation

Review of 112 patients with Wegener's granulomatosis showed that 21 (19%) had ear involvement. Conductive deafness, which was present in all 21 patients, was due to serous middle ear fluid, suppurative otitis media with thickening of the tympanic membrane, perforation of the tympanic membrane, or granulation tissue in the middle ear space. Nine patients also had sensorineural hearing loss. Sensorineural hearing loss was improved in five of the nine patients after control of the disease with prednisone and cyclophosphamide.

Recovery from sensorineural deafness in Wegener's granulomatosis

1989 ◽  
Vol 103 (5) ◽  
pp. 515-518 ◽  
Author(s):  
M. R. Clements ◽  
C. D. Mistry ◽  
A. O. Keith ◽  
R. T. Ramsden
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Wegener’S Granulomatosis ◽  
Sensorineural Deafness ◽  
Complete Recovery ◽  
Wegener's Granulomatosis ◽  
Sensorineural Hearing ◽  
High Dose ◽  
Histological Evidence ◽  
Maintenance Haemodialysis

AbstractWegener's granulomatosis may present with deafness or other aural symptoms. This report describes two patients with histological evidence of Wegener's granulomatosis who developed reversible sensorineural hearing loss during the course of their illness. The first patient showed complete recovery of a sensorineural hearing loss averaging 50 dB after ten months treatment with cyclophosphamide and high-dose prednisolone. The second patient, who was on maintenance haemodialysis, achieved a 40 dB improvement in sensorineural hearing loss within two weeks of adding cyclophosphamide to pre-existing corticosteroid therapy. These findings suggest that the prognosis of sensorineural hearing loss in Wegener's granulomatosis can be improved with suppression of the vasculitic process by early treatment with combined cytotoxic-immunosuppressive therapy

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