Audiological findings in a Phase I protocol investigating the effect of WR 2721, high-dose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma

1995 ◽  
Vol 109 (8) ◽  
pp. 744-747 ◽  
Author(s):  
John S. Rubin ◽  
Scott Wadler ◽  
Jonathan J. Baitler ◽  
Hilda Haynes ◽  
Alla Rozenblet ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Phase I ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
Hearing Threshold ◽  
High Dose ◽  
High Frequencies ◽  
Advanced Cervical Carcinoma ◽  
Before And After ◽  
Audiologic Testing

AbstractWR 2721 (ethiofos) protects against the toxic effects of the heavy metal compound cisplatin. which is used in the treatment of solid tumours. In a Phase I protocol designed to determine the maximum dose of WR 2721 which could be tolerated when administered in combination with cisplatin and radiation therapy to patients with cervical carcinoma. 11 patients were evaluated by audiologic testing before and after cisplatin WR 2721 administration in an attempt to identify the degree of ototoxicity. Forty-five per cent were noted to have significant hearing threshold changes. predominantly in the high frequencies. There were no significant changes in the speech frequencies in this series. This contrasts with the greater degrees of ototoxicity observed in controls treated in the same way who received cisplatin without WR 2721 protection.

scholarly journals Concurrent chemoradiation in treatment of carcinoma cervix

1970 ◽  
Vol 2 (1) ◽  
pp. 4-8
Author(s):  
Meeta Singh ◽  
Rajshree Jha ◽  
Josie Baral ◽  
Suniti Rawal
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
Concurrent Chemoradiation ◽  
Advanced Cervical Cancer ◽  
European Organization ◽  
Locally Advanced Cervical Cancer ◽  
Advanced Cervical Carcinoma ◽  
To Come

Aim: to compare if concurrent chemoradiation is better than radiotherapy given alone in the treatment of women with locally advanced cervical cancer from published literature Method: Study Design: Randomized control trials of > than 2, 403 women participants who underwent treatment for advanced cervical carcinoma mainly in two huge center i.e. from National Cancer Institute (NCI), USA and European Organization for Research and Treatment of Cancer (EORTC) were reviewed regarding the treatment they received at the center: concurrent chemoradiation/ radiation therapy alone. The results were analyzed to come to conclusion. Result demonstrated a 30-50% improvement in survival when cisplatin-based chemotherapy in NCI or 5 fluorouracil and cisplatin based chemotherapy was used in EORTC was administered with concurrent radiation therapy (chemoradiation) Conclusions: The addition of chemotherapy (cisplatin) in NCI and (cisplatin and fluorouracil) in the EORTC for the treatment of locally advanced cervical cancer with the concurrent chemoradition have elicited better survival than those treated with radiotherapy alone dittoed by several other trials which can be anticipated to benefit Nepalese women with locally advanced cervical carcinoma. Key-words: Cancer cervix, chemoradiation, radiotherapy   doi:10.3126/njog.v2i1.1467 N. J. Obstet. Gynaecol Vol. 2, No. 1, p. 4 - 8 May -June 2007

scholarly journals Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma

2010 ◽  
Author(s):  
Ludy Lutgens ◽  
Jacoba van der Zee ◽  
Madelon Pijls-Johannesma ◽  
Danielle FM De Haas-Kock ◽  
Jeroen Buijsen ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
Advanced Cervical Carcinoma ◽  
Combined Use

High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: A preliminary report

1991 ◽  
Vol 41 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Pierluigi Benedetti Panici ◽  
Stefano Greggi ◽  
Giovanni Scambia ◽  
Guglielmo Ragusa ◽  
Gabriela Baiocchi ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Cervical Carcinoma ◽  
Preliminary Report ◽  
Radical Surgery ◽  
Locally Advanced ◽  
High Dose ◽  
Advanced Cervical Carcinoma

Phase I–II Trial of Preoperative Chemoradiation in Locally Advanced Cervical Carcinoma

2000 ◽  
Vol 78 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Salvatore Mancuso ◽  
Daniela Smaniotto ◽  
Pierluigi Benedetti Panici ◽  
Barbara Favale ◽  
Stefano Greggi ◽  
...  
Keyword(s):  
Phase I ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
Preoperative Chemoradiation ◽  
Advanced Cervical Carcinoma

High–dose rate interstitial brachytherapy using two weekly sessions of 10Gy each for patients with locally advanced cervical carcinoma

Brachytherapy ◽  
2011 ◽  
Vol 10 (3) ◽  
pp. 242-248 ◽  
Author(s):  
Daya Nand Sharma ◽  
Goura Kisor Rath ◽  
Sanjay Thulkar ◽  
Sunesh Kumar ◽  
Vellaiyan Subramani ◽  
...  
Keyword(s):  
Dose Rate ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
High Dose Rate ◽  
Interstitial Brachytherapy ◽  
High Dose ◽  
Advanced Cervical Carcinoma

scholarly journals A phase I–II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervical carcinoma

2003 ◽  
Vol 14 (8) ◽  
pp. 1285-1290 ◽  
Author(s):  
J.J. Zarbá ◽  
A.V. Jaremtchuk ◽  
P. Gonzalez Jazey ◽  
M. Keropian ◽  
R. Castagnino ◽  
...  
Keyword(s):  
Phase I ◽  
Cervical Carcinoma ◽  
Locally Advanced ◽  
Concurrent Radiotherapy ◽  
Advanced Cervical Carcinoma ◽  
Weekly Cisplatin
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