The NGF superfamily of neurotrophins: Potential treatment for Alzheimer's and Parkinson's disease

1995 ◽  
Vol 18 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Elliott J. Mufson ◽  
Teresa Sobreviela
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Forebrain ◽  
Tyrosine Kinase Receptors ◽  
Potential Treatment ◽  
Neuron Degeneration ◽  
Cholinergic Basal Forebrain ◽  
The Family ◽  
Substantia Nigra Neuron ◽  
Tissue Grafts

AbstractStein & Glasier suggest embryonic neural tissue grafts as a potential treatment strategy for Alzheimer's and Parkinson's disease. As an alternative, we suggest that the family of nerve growth factor-related neurotrophins and their trk (tyrosine kinase) receptors underlie cholinergic basal forebrain (CBF) and dopaminergic substantia nigra neuron degeneration in these diseases, respectively. Therefore, treatment approaches for these disorders could utilize neurotrophins.

scholarly journals In vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: imaging results from the COPPADIS study

2021 ◽  
Author(s):  
Michel J. Grothe ◽  
Miguel A. Labrardor-Espinosa ◽  
Silvia Jesús ◽  
Daniel Macías-García ◽  
Astrid Adarmes-Gómez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Forebrain ◽  
Cholinergic Basal Forebrain ◽  
Imaging Results

scholarly journals In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson’s disease

Brain ◽  
2017 ◽  
Vol 141 (1) ◽  
pp. 165-176 ◽  
Author(s):  
Nicola J Ray ◽  
Steven Bradburn ◽  
Christopher Murgatroyd ◽  
Umar Toseeb ◽  
Pablo Mir ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Basal Forebrain ◽  
De Novo ◽  
Cholinergic Basal Forebrain

scholarly journals Cholinergic Basal Forebrain Volumes Predict Gait Decline in Parkinson's Disease

2020 ◽  
Author(s):  
Joanna Wilson ◽  
Alison J. Yarnall ◽  
Chesney E. Craig ◽  
Brook Galna ◽  
Sue Lord ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Forebrain ◽  
Cholinergic Basal Forebrain

Problems of family caregivers of people with Parkinson’s disease as a challenge for social work

2021 ◽  
Vol 36 (1) ◽  
pp. 97-119
Author(s):  
Beata Szluz
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Social Work ◽  
Family Caregivers ◽  
Elderly Person ◽  
Chronically Ill ◽  
Financial Costs ◽  
The People ◽  
Depth Interview ◽  
The Family

Due to the aging of societies the increased prevalence of patients with dementia is observed. Parkinson’s disease is one of the most frequent neurodegenerative disorders and occurs mainly among the people agedover 50 years. Caring for a person with Parkinson’s disease is not only exhausting physically and emotionally, but it also meanshigh financial costs. Caring is associated with a high risk of a decreasedquality of life, it is especially in case of the family caregivers who are emotionally attached to the patient. The article attempts to show the problems associated with caring for a person with Parkinson’s disease that set tasks for social work with a family experiencing disease and disability. The survey was conducted in July 2019 in the Podkarpackie Voivodeship, using the (In-Depth Interview – IDI technique. The study was qualitative. Its assumption was not to obtain representative data characterizing the family caregivers of people with Parkinson’s disease, but to try to capture how the problems associated with caring for this category of patients burden caregivers and to what extent they expect support (supporting supporters). Presenting the burden on family caregivers in the light of qualitative research made it possible to identify the specific tasks facing a social worker who works with the family of a chronically ill elderly person and to propose a training program for caregivers.

A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease

1996 ◽  
Vol 140 (1-2) ◽  
pp. 40-45 ◽  
Author(s):  
Shuang Yong Ma ◽  
Juha O. Rinne ◽  
Yrjö Collan ◽  
Matias Röyttä ◽  
Urpo K. Rinne
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Neuron Degeneration ◽  
Morphometrical Study

Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease

2019 ◽  
Vol 29 (7) ◽  
pp. 929-932 ◽  
Author(s):  
Dominique Lesuisse ◽  
André Malanda ◽  
Jean-François Peyronel ◽  
Yannick Evanno ◽  
Patrick Lardenois ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Potential Treatment

scholarly journals Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease

2020 ◽  
Vol 139 ◽  
pp. 104831 ◽  
Author(s):  
Joana B. Pereira ◽  
Sara Hall ◽  
Mattis Jalakas ◽  
Michel J. Grothe ◽  
Olof Strandberg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Forebrain
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