Near-Infrared Spectrometric Determination of Di- and Tripeptides Synthesized by a Combinatorial Solid-Phase Method

Analogs of angiotensin II in which phenylalanine in position 8 was replaced with cymantrenylalanine or with its triphenylphosphine photosubstitution product were synthesized by the solid-phase method. On rabbit aorta strips, these peptides were found to be pure antagonists of angiotensin II. Their relative affinities are higher than most other analogs substituted in position 8 with bulky amino-acids.

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Synthesis of four new V1 antagonists of arginine-vasopressin (AVP) containing new thioacids at position 1 and their vasoconstrictor activity towards isolated mesenteric arterial vessels of rats

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19910491 ◽

1991 ◽

Vol 56 (2) ◽

pp. 491-498 ◽

Cited By ~ 4

Author(s):

Bernard Lammek ◽

Izabela Derdowska ◽

Tomasz M. Wierzba ◽

Witold Juzwa

Keyword(s):

Peptide Synthesis ◽

Arginine Vasopressin ◽

Solid Phase ◽

Structural Features ◽

Phase Method ◽

Competitive Antagonist ◽

Vasoconstrictor Effect ◽

Solid Phase Method

In an attempt to determine some of the structural features in position 1 that account for V1 antagonism, four new analogues of arginine-vasopressin were synthesized and the effect of the modifications on the vasoconstrictor activity was checked using isolated mesenteric arterial vessels of rats. The protected precursors required for these analogues were synthesized by a solid phase method of peptide synthesis. One of the reported analogues, namely [1-(4-mercapto-4-tetrahydrothiopyraneacetic acid)., 2-O-methyltyrosine, 8-arginine]vasopressin appears to be a potent competitive antagonist of the vasoconstrictor effect by AVP.

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Synthesis of a 21-Residue Fragment of Human Proinsulin by the Polyamide Solid Phase Method

Hoppe-Seyler´s Zeitschrift für physiologische Chemie ◽

10.1515/bchm2.1981.362.2.833 ◽

1981 ◽

Vol 362 (2) ◽

pp. 833-840 ◽

Cited By ~ 13

Author(s):

Eric ATHERTON ◽

Willy HÜBSCHER ◽

Robert C. SHEPPARD ◽

Vivienne WOOLLEY

Keyword(s):

Solid Phase ◽

Phase Method ◽

Human Proinsulin ◽

Solid Phase Method

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Syntheses of two deacetyl-thymosin β4analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw

Mediators of Inflammation ◽

10.1080/09629350120054563 ◽

2001 ◽

Vol 10 (2) ◽

pp. 89-92 ◽

Cited By ~ 2

Author(s):

T. Abiko ◽

R. Ogawa

Keyword(s):

Marked Reduction ◽

Solid Phase ◽

The Other ◽

Para Position ◽

Phase Method ◽

Antiinflammatory Effect ◽

Solid Phase Method ◽

Anti Inflammatory ◽

Inflammatory Effect

Two {Met(0)6}deacetyl-thymosin β4analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)6}deacetyl-thymosin β4, but the other analog, {Met(0)6, Tyr(Me)12}deacetyl-thymosin β4, showed a marked reduction of the anti-inflammatory effect.

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The Gas-Solid-Phase 2,5-Dioxopiperazine Synthesis. Cyclization of Vaporous Dipeptides on Silica Surface

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19940461 ◽

1994 ◽

Vol 59 (2) ◽

pp. 461-466 ◽

Cited By ~ 12

Author(s):

Vladimir A. Basiuk ◽

Taras Yu. Gromovoy

Keyword(s):

Silica Surface ◽

Solid Phase ◽

Phase Method ◽

Solid Phase Method

The "gas solid-phase" method is used for the preparation of both symmetric and asymmetric 2,5-dioxopiperazines via cyclization of vaporous linear dipeptides in the presence of silica.

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