N-Nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation

Pharmacology & Therapeutics ◽

10.1016/0163-7258(96)00062-9 ◽

1996 ◽

Vol 71 (1-2) ◽

pp. 57-81 ◽

Author(s):

L Verna

Keyword(s):

Risk Assessment ◽

Adduct Formation ◽

Tumor Initiation

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Organ specificity of DNA adduct formation by tamoxifen and α-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment

Mutagenesis ◽

10.1093/mutage/gei038 ◽

2005 ◽

Vol 20 (4) ◽

pp. 297-303 ◽

Author(s):

David H. Phillips ◽

Alan Hewer ◽

Martin R. Osborne ◽

Kathleen J. Cole ◽

Cyd Churchill ◽

...

Keyword(s):

Risk Assessment ◽

Adduct Formation ◽

Organ Specificity ◽

Human Risk Assessment ◽

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Metabolic Activation of Pyrrolizidine Alkaloids – Generation of Multiple Reactive Metabolites Leading to DNA Adduct Formation and Potentially Liver Tumor Initiation

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.08851 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Qingsu Xia ◽

Xiaobo He ◽

Ge Lin ◽

Peter P. Fu

Keyword(s):

Liver Tumor ◽

Pyrrolizidine Alkaloids ◽

Metabolic Activation ◽

Adduct Formation ◽

Reactive Metabolites ◽

Tumor Initiation

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Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.8b00096 ◽

2018 ◽

Vol 31 (7) ◽

pp. 619-628 ◽

Author(s):

Qingsu Xia ◽

Xiaobo He ◽

Liang Ma ◽

Shoujun Chen ◽

Peter P. Fu

Keyword(s):

Liver Tumor ◽

Pyrrolizidine Alkaloid ◽

Adduct Formation ◽

Tumor Initiation ◽

Activation Pathways

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Formaldehyde mechanistic data and risk assessment: Endogenous protection from DNA adduct formation

Pharmacology & Therapeutics ◽

10.1016/0163-7258(96)00061-7 ◽

1996 ◽

Vol 71 (1-2) ◽

pp. 29-55 ◽

Author(s):

C.Clifford Conaway ◽

John Whysner ◽

Lynne K. Verna ◽

Gary M. Williams

Keyword(s):

Risk Assessment ◽

Adduct Formation ◽

Endogenous Protection

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Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice

Carcinogenesis ◽

10.1093/carcin/23.10.1667 ◽

2002 ◽

Vol 23 (10) ◽

pp. 1667-1675 ◽

Author(s):

H. E. Kleiner

Keyword(s):

Oral Administration ◽

Adduct Formation ◽

Tumor Initiation

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Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy

Environmental Science & Technology ◽

10.1021/acs.est.1c00648 ◽

2021 ◽

Author(s):

Wanlin Guo ◽

Jiayin Zhang ◽

Zhihan Sun ◽

William H. Orem ◽

Calin A. Tatu ◽

...

Keyword(s):

Aristolochic Acid ◽

Phthalate Esters ◽

Balkan Peninsula ◽

Adduct Formation ◽

Balkan Endemic Nephropathy ◽

Food Grains ◽

Polycyclic Aromatic ◽

Endemic Nephropathy ◽

Aristolochic Acid I

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Cytochrome P-450 Isoforms Implicated in Ochratoxin A Genotoxicity Determined by DNA Adduct Formation

Clinical Chemistry ◽

10.1093/clinchem/41.12.1927 ◽

1995 ◽

Vol 41 (12) ◽

pp. 1927-1929 ◽

Keyword(s):

Ochratoxin A ◽

Adduct Formation ◽

Cytochrome P 450

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Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

Chemical Research in Toxicology ◽

10.1021/tx9802318 ◽

1999 ◽

Vol 12 (2) ◽

pp. 180-186 ◽

Author(s):

Young-Heum Chae ◽

Ben-Yi Ji ◽

Jyh-Ming Lin ◽

Peter P. Fu ◽

Bongsup P. Cho ◽

...

Keyword(s):

Mammary Gland ◽

Adduct Formation ◽

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NADH:cytochrome b5 reductase and cytochrome b5 act as sole electron donors to human cytochrome P450 1A1-catalyzed oxidation and DNA adduct formation by benzo[a]pyrene

Toxicology Letters ◽

10.1016/j.toxlet.2016.06.1417 ◽

2016 ◽

Vol 258 ◽

pp. S96

Author(s):

M. Stiborova ◽

I. Radek ◽

M. Moserova ◽

E. Frei ◽

K. Kopka ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Adduct Formation ◽

Electron Donors ◽

Cytochrome P450 1A1 ◽

Human Cytochrome ◽

Catalyzed Oxidation

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Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2

Carcinogenesis ◽

10.1093/carcin/bgw006 ◽

2016 ◽

Vol 37 (3) ◽

pp. 314-319 ◽

Author(s):

Benjamin Sachse ◽

Walter Meinl ◽

Hansruedi Glatt ◽

Bernhard H. Monien

Keyword(s):

Furfuryl Alcohol ◽

Adduct Formation ◽

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