Inhibition Mechanism of Antimalarial Drugs Targeting the Cytochrome bc1 Complex

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.0c01148 ◽

2021 ◽

Author(s):

Luise Jacobsen ◽

Peter Husen ◽

Ilia A. Solov’yov

Keyword(s):

Antimalarial Drugs ◽

Cytochrome Bc1 ◽

Inhibition Mechanism ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex

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The mitochondrial targeting presequence of the Rieske iron-sulfur protein is processed in a single step after insertion into the cytochrome bc1 complex in mammals and retained as a subunit in the complex.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)52883-0 ◽

1993 ◽

Vol 268 (12) ◽

pp. 8387-8390

Author(s):

U. Brandt ◽

L. Yu ◽

C.A. Yu ◽

B.L. Trumpower

Keyword(s):

Single Step ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Mitochondrial Targeting ◽

Cytochrome Bc1 Complex ◽

Iron Sulfur ◽

A Subunit ◽

Sulfur Protein ◽

Iron Sulfur Protein ◽

Rieske Iron Sulfur Protein

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An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(20)82143-7 ◽

1984 ◽

Vol 259 (10) ◽

pp. 6318-6326 ◽

Author(s):

G von Jagow ◽

P O Ljungdahl ◽

P Graf ◽

T Ohnishi ◽

B L Trumpower

Keyword(s):

Cytochrome B ◽

Mitochondrial Respiration ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

Iron Sulfur ◽

Sulfur Protein ◽

Iron Sulfur Protein

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Biogenesis of mitochondrial ubiquinol:cytochrome c reductase (cytochrome bc1 complex). Precursor proteins and their transfer into mitochondria.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)34028-6 ◽

1982 ◽

Vol 257 (17) ◽

pp. 10364-10371 ◽

Author(s):

M Teintze ◽

M Slaughter ◽

H Weiss ◽

W Neupert

Keyword(s):

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

Precursor Proteins ◽

Complex Precursor

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Subunit 6 regulates half-of-the-sites reactivity of the dimeric cytochrome bc1 complex in Saccharomyces cerevisiae.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)44860-5 ◽

1990 ◽

Vol 265 (28) ◽

pp. 17005-17011 ◽

Author(s):

M E Schmitt ◽

B L Trumpower

Keyword(s):

Saccharomyces Cerevisiae ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex

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Deletion of QCR6, the gene encoding subunit six of the mitochondrial cytochrome bc1 complex, blocks maturation of cytochrome c1, and causes temperature-sensitive petite growth in Saccharomyces cerevisiae.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)42253-8 ◽

1994 ◽

Vol 269 (2) ◽

pp. 1270-1275

Author(s):

M. Yang ◽

B.L. Trumpower

Keyword(s):

Saccharomyces Cerevisiae ◽

Cytochrome Bc1 ◽

Temperature Sensitive ◽

Mitochondrial Cytochrome ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

Gene Encoding ◽

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The petite phenotype resulting from a truncated copy of subunit 6 results from loss of assembly of the cytochrome bc1 complex and can be suppressed by overexpression of subunit 9

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)98571-6 ◽

1991 ◽

Vol 266 (23) ◽

pp. 14958-14963

Author(s):

M.E. Schmitt ◽

B.L. Trumpower

Keyword(s):

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

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Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)99967-9 ◽

1994 ◽

Vol 269 (17) ◽

pp. 12947-12953

Author(s):

U. Brandt ◽

S. Uribe ◽

H. Schägger ◽

B.L. Trumpower

Keyword(s):

Saccharomyces Cerevisiae ◽

Nuclear Gene ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

Gene Encoding ◽

Isolation And Characterization

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A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc1 Complex

Journal of Molecular Biology ◽

10.1016/j.jmb.2007.02.013 ◽

2007 ◽

Vol 368 (1) ◽

pp. 197-208 ◽

Author(s):

C. Roy D. Lancaster ◽

Carola Hunte ◽

Jack Kelley ◽

Bernard L. Trumpower ◽

Robert Ditchfield

Keyword(s):

Reaction Center ◽

Photosynthetic Reaction Center ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex

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Inter- and intra-molecular electron transfer in the cytochrome bc1 complex

Biochimica et Biophysica Acta (BBA) - Bioenergetics ◽

10.1016/s0005-2728(02)00256-6 ◽

2002 ◽

Vol 1555 (1-3) ◽

pp. 65-70 ◽

Author(s):

Chang-An Yu ◽

Xiaolin Wen ◽

Kunhong Xiao ◽

Di Xia ◽

Linda Yu

Keyword(s):

Electron Transfer ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex ◽

Molecular Electron

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Inhibition of Reversed Electron Transfer and Proton Transport in the Beef Heart Cytochrome bc1 Complex by Chemical Modification

The Journal of Biochemistry ◽

10.1093/jb/mvm042 ◽

2006 ◽

Vol 141 (3) ◽

pp. 377-387 ◽

Author(s):

T. Miki ◽

M. Umeda ◽

Y. Harada

Keyword(s):

Electron Transfer ◽

Chemical Modification ◽

Proton Transport ◽

Cytochrome Bc1 ◽

Bc1 Complex ◽

Cytochrome Bc1 Complex

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