ProBiS-Dock Database: A Web Server and Interactive Web Repository of Small Ligand–Protein Binding Sites for Drug Design

2021 ◽  
Author(s):  
Janez Konc ◽  
Samo Lešnik ◽  
Blaž Škrlj ◽  
Dušanka Janežič
Keyword(s):  
Drug Design ◽  
Protein Binding ◽  
Binding Sites ◽  
Web Server ◽  
Protein Binding Sites ◽  
Web Repository

A novel approach to local similarity of protein binding sites substantially improves computational drug design results

2007 ◽  
Vol 69 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Vasily Ramensky ◽  
Alexandr Sobol ◽  
Natalia Zaitseva ◽  
Anatoly Rubinov ◽  
Victor Zosimov
Keyword(s):  
Drug Design ◽  
Protein Binding ◽  
Binding Sites ◽  
Local Similarity ◽  
Computational Drug Design ◽  
Protein Binding Sites ◽  
Novel Approach

SitePrint: Three-Dimensional Pharmacophore Descriptors Derived from Protein Binding Sites for Family Based Active Site Analysis, Classification, and Drug Design.

ChemInform ◽  
2005 ◽  
Vol 36 (9) ◽  
Author(s):  
James R. Arnold ◽  
Keith W. Burdick ◽  
Scott C.-H. Pegg ◽  
Samuel Toba ◽  
Michelle L. Lamb ◽  
...  
Keyword(s):  
Drug Design ◽  
Protein Binding ◽  
Active Site ◽  
Binding Sites ◽  
Three Dimensional ◽  
Protein Binding Sites ◽  
Site Analysis ◽  
Family Based

scholarly journals GenProBiS: web server for mapping of sequence variants to protein binding sites

2017 ◽  
Vol 45 (W1) ◽  
pp. W253-W259 ◽  
Author(s):  
Janez Konc ◽  
Blaz Skrlj ◽  
Nika Erzen ◽  
Tanja Kunej ◽  
Dusanka Janezic
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Web Server ◽  
Sequence Variants ◽  
Protein Binding Sites

scholarly journals PBSword: a web server for searching similar protein-protein binding sites

2012 ◽  
Vol 40 (W1) ◽  
pp. W428-W434 ◽  
Author(s):  
B. Pang ◽  
X. Kuang ◽  
N. Zhao ◽  
D. Korkin ◽  
C.-R. Shyu
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Web Server ◽  
Protein Binding Sites ◽  
Similar Protein

scholarly journals PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes

2004 ◽  
Vol 32 (Web Server) ◽  
pp. W318-W320 ◽  
Author(s):  
S. Yellaboina ◽  
J. Seshadri ◽  
M. S. Kumar ◽  
A. Ranjan
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Regulatory Protein ◽  
Web Server ◽  
Protein Binding Sites

EVALUATION OF TISSUE STEROID BINDING IN VITRO

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S223-S246 ◽  
Author(s):  
C. R. Wira ◽  
H. Rochefort ◽  
E. E. Baulieu
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Experimental System ◽  
Specific Protein ◽  
Coupling Mechanism ◽  
Target Tissue ◽  
Protein Binding Sites ◽  
Definition Of ◽  
Hormone Specificity

ABSTRACT The definition of a RECEPTOR* in terms of a receptive site, an executive site and a coupling mechanism, is followed by a general consideration of four binding criteria, which include hormone specificity, tissue specificity, high affinity and saturation, essential for distinguishing between specific and nonspecific binding. Experimental approaches are proposed for choosing an experimental system (either organized or soluble) and detecting the presence of protein binding sites. Techniques are then presented for evaluating the specific protein binding sites (receptors) in terms of the four criteria. This is followed by a brief consideration of how receptors may be located in cells and characterized when extracted. Finally various examples of oestrogen, androgen, progestagen, glucocorticoid and mineralocorticoid binding to their respective target tissues are presented, to illustrate how researchers have identified specific corticoid and mineralocorticoid binding in their respective target tissue receptors.

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