GalaxyGPCRloop: Template-Based and Ab Initio Structure Sampling of the Extracellular Loops of G-Protein-Coupled Receptors

2018 ◽  
Vol 58 (6) ◽  
pp. 1234-1243 ◽  
Author(s):  
Jonghun Won ◽  
Gyu Rie Lee ◽  
Hahnbeom Park ◽  
Chaok Seok
Keyword(s):  
Ab Initio ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Extracellular Loops ◽  
Ab Initio Structure ◽  
G Protein Coupled

Integrated Web-Based ab initio Modeling Platform for G-protein Coupled Receptors

2011 ◽  
Vol 8 (2) ◽  
pp. 159-171
Author(s):  
Govindan Subramanian ◽  
Manish Sud ◽  
Sam Billakanti ◽  
Adel Laoui
Keyword(s):  
Ab Initio ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Web Based ◽  
Ab Initio Modeling ◽  
G Protein Coupled

Ab initio computational modeling of long loops in G-protein coupled receptors

2006 ◽  
Vol 20 (7-8) ◽  
pp. 427-436 ◽  
Author(s):  
Sandhya Kortagere ◽  
Amitava Roy ◽  
Ernest L. Mehler
Keyword(s):  
Computational Modeling ◽  
Ab Initio ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

Enzymatic recycling of ascorbic acid from dehydroascorbic acid by glutathione-like peptides in the extracellular loops of aminergic G-protein coupled receptors

2016 ◽  
Vol 29 (7) ◽  
pp. 296-302 ◽  
Author(s):  
Robert Root-Bernstein ◽  
Jenna Fewins ◽  
Tyler Rhinesmith ◽  
Ariana Koch ◽  
Patrick F. Dillon
Keyword(s):  
Ascorbic Acid ◽  
G Protein ◽  
Dehydroascorbic Acid ◽  
G Protein Coupled Receptors ◽  
Extracellular Loops ◽  
G Protein Coupled

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

2007 ◽  
Vol 35 (4) ◽  
pp. 717-720 ◽  
Author(s):  
M. Wheatley ◽  
J. Simms ◽  
S.R. Hawtin ◽  
V.J. Wesley ◽  
D. Wootten ◽  
...  
Keyword(s):  
Ligand Binding ◽  
G Protein ◽  
Tertiary Structure ◽  
Large Family ◽  
Peptide Hormone ◽  
Receptor Activation ◽  
G Protein Coupled Receptors ◽  
Ligand Selectivity ◽  
Extracellular Loops ◽  
G Protein Coupled

GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins which mediate their effects by coupling to G-proteins. The V1aR (V1a vasopressin receptor) is a member of a family of related GPCRs that are activated by vasopressin {AVP ([Arg8]vasopressin)}, OT (oxytocin) and related peptides. These receptors are members of a subfamily of Family A GPCRs called the neurohypophysial peptide hormone receptor family. GPCRs exhibit a conserved tertiary structure comprising a bundle of seven TM (transmembrane) helices linked by alternating ECLs (extracellular loops) and ICLs (intracellular loops). The cluster of TM helices is functionally important for ligand binding, and, furthermore, activation of GPCRs involves movement of these TM helices. Consequently, it might be assumed that the extracellular face of GPCRs is composed of peptide linkers that merely connect important TM helices. However, using a systematic mutagenesis approach and focusing on the N-terminus and the second ECL of the V1aR, we have established that these extracellular domains fulfil a range of important roles with respect to GPCR signalling, including agonist binding, ligand selectivity and receptor activation.

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