Enantioselective Synthesis of α-Aryl-β-Aminocyclopropane Carboxylic Acid Derivatives via Rh(II)-Catalyzed Cyclopropanation of Vinylsulfonamides with α-Aryldiazoesters

2022 ◽  
Author(s):  
Yuqi Zhu ◽  
Ting Zhou ◽  
Hong Zhang ◽  
Jieyin He ◽  
Hongguang Li ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Enantioselective Synthesis

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

Rapid Development of an Enantioselective Synthesis of (R)-1-Hydroxy-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic Acid

2003 ◽  
Vol 7 (2) ◽  
pp. 198-201 ◽  
Author(s):  
Debra Ainge ◽  
David Ennis ◽  
Malin Gidlund ◽  
Marijan Stefinovic ◽  
Luis-Manuel Vaz
Keyword(s):  
Carboxylic Acid ◽  
Rapid Development ◽  
Enantioselective Synthesis

ChemInform Abstract: Enantioselective Synthesis of Aminoindan Carboxylic Acid Derivatives by the Catalytic Intramolecular [2 + 2 + 2] Cycloaddition of Amino-Acid-Tethered Triynes.

ChemInform ◽  
2016 ◽  
Vol 47 (29) ◽  
Author(s):  
Yu-ki Tahara ◽  
Shuhei Obinata ◽  
Kyalo Stephen Kanyiva ◽  
Takanori Shibata ◽  
Attila Mandi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Enantioselective Synthesis
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