Duplex DNA and DNA–RNA Hybrids with Parallel Strand Orientation: 2′-Deoxy-2′-fluoroisocytidine, 2′-Deoxy-2′-fluoroisoguanosine, and Canonical Nucleosides with 2′-Fluoro Substituents Cause Unexpected Changes on the Double Helix Stability

2015 ◽  
Vol 80 (6) ◽  
pp. 3124-3138 ◽  
Author(s):  
Sachin A. Ingale ◽  
Peter Leonard ◽  
Quang Nhat Tran ◽  
Frank Seela
Keyword(s):  
Double Helix ◽  
Duplex Dna ◽  
Strand Orientation ◽  
Helix Stability

Na2CO3Influence on DNA Double Helix Stability: Strong Anion Destabilizing Effect

2003 ◽  
Vol 20 (6) ◽  
pp. 801-809 ◽  
Author(s):  
Elena N. Galyuk ◽  
Dmitri Y. Lando ◽  
Valentina P. Egorova ◽  
Hwa Dai ◽  
Yury M. Dosin
Keyword(s):  
Double Helix ◽  
Helix Stability ◽  
Dna Double Helix

DNA with Parallel Strand Orientation: A Nanometer Distance Study with Spin Labels in the Watson–Crick and the Reverse Watson–Crick Double Helix

2015 ◽  
Vol 119 (43) ◽  
pp. 13593-13599 ◽  
Author(s):  
Dorith Wunnicke ◽  
Ping Ding ◽  
Haozhe Yang ◽  
Frank Seela ◽  
Heinz-Jürgen Steinhoff
Keyword(s):  
Double Helix ◽  
Spin Labels ◽  
Strand Orientation

scholarly journals An overview of recent advances in duplex DNA recognition by small molecules

2018 ◽  
Vol 14 ◽  
pp. 1051-1086 ◽  
Author(s):  
Sayantan Bhaduri ◽  
Nihar Ranjan ◽  
Dev P Arya
Keyword(s):  
Small Molecules ◽  
Double Helix ◽  
Dna Recognition ◽  
Duplex Dna ◽  
Synthetic Dna ◽  
Natural Ligands ◽  
Dna Protein Interaction ◽  
Dna Binders ◽  
Dna Double Helix ◽  
A Site

As the carrier of genetic information, the DNA double helix interacts with many natural ligands during the cell cycle, and is amenable to such intervention in diseases such as cancer biogenesis. Proteins bind DNA in a site-specific manner, not only distinguishing between the geometry of the major and minor grooves, but also by making close contacts with individual bases within the local helix architecture. Over the last four decades, much research has been reported on the development of small non-natural ligands as therapeutics to either block, or in some cases, mimic a DNA–protein interaction of interest. This review presents the latest findings in the pursuit of novel synthetic DNA binders. This article provides recent coverage of major strategies (such as groove recognition, intercalation and cross-linking) adopted in the duplex DNA recognition by small molecules, with an emphasis on major works of the past few years.

Theory of the influence of oligonucleotide chain conformation on double helix stability

Biopolymers ◽  
1971 ◽  
Vol 10 (10) ◽  
pp. 1809-1827 ◽  
Author(s):  
C. Delisi ◽  
D. M. Crothers
Keyword(s):  
Double Helix ◽  
Chain Conformation ◽  
Helix Stability

scholarly journals DNA and RNA oligomer thermodynamics: The effect of mismatched bases on double-helix stability

Biopolymers ◽  
1981 ◽  
Vol 20 (12) ◽  
pp. 2509-2531 ◽  
Author(s):  
Jeffrey W. Nelson ◽  
Francis H. Martin ◽  
Ignacio Tinoco
Keyword(s):  
Double Helix ◽  
Dna And Rna ◽  
Helix Stability

scholarly journals Double-stranded DNA fragment shows a significant decrease in double-helix stability after binding of monofunctional platinum amine compounds

1989 ◽  
Vol 111 (11) ◽  
pp. 4123-4125 ◽  
Author(s):  
Carla J. Van Garderen ◽  
Leo P. A. Van Houte ◽  
Hans Van den Elst ◽  
Jacques H. Van Boom ◽  
Jan Reedijk
Keyword(s):  
Double Helix ◽  
Double Stranded Dna ◽  
Helix Stability ◽  
Dna Fragment ◽  
Amine Compounds
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