Design, Synthesis, and Conformational Analysis of Oligobenzanilides as Multifacial α-Helix Mimetics

3-cyclo-Butylcarbamoyl hydantoins are able to mimic α-helix and β-turn secondary structures as assessed by molecular modeling, NMR studies, and X-ray analysis.

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Synthesis of Pyridazine-Based Scaffolds as α-Helix Mimetics

Organic Letters ◽

10.1021/ol701487g ◽

2007 ◽

Vol 9 (19) ◽

pp. 3733-3736 ◽

Cited By ~ 64

Author(s):

Alessandro Volonterio ◽

Lionel Moisan ◽

Julius Rebek

Keyword(s):

Helix Mimetics ◽

Α Helix

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The Development of a Modular Synthesis of Teraryl-Based α-Helix Mimetics as Potential Inhibitors of Protein–Protein Interactions

Synlett ◽

10.1055/s-0033-1340740 ◽

2014 ◽

Vol 25 (09) ◽

pp. 1202-1214 ◽

Cited By ~ 7

Author(s):

Rolf Breinbauer ◽

Melanie Trobe ◽

Martin Peters ◽

Sebastian Grimm

Keyword(s):

Protein Interactions ◽

Protein Protein Interactions ◽

Modular Synthesis ◽

Helix Mimetics ◽

Α Helix ◽

Potential Inhibitors

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Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics

Tetrahedron ◽

10.1016/j.tet.2012.11.070 ◽

2013 ◽

Vol 69 (5) ◽

pp. 1663-1668 ◽

Cited By ~ 9

Author(s):

Christopher G. Cummings ◽

Andrew D. Hamilton

Keyword(s):

Water Soluble ◽

Helix Mimetics ◽

Α Helix

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ChemInform Abstract: Design, Synthesis, and Conformational Analysis of Compounds Tailored for the Study of Sulfur-Centered Reactive Intermediates

ChemInform ◽

10.1002/chin.199137297 ◽

2010 ◽

Vol 22 (37) ◽

pp. no-no

Author(s):

R. S. GLASS

Keyword(s):

Conformational Analysis ◽

Reactive Intermediates ◽

Design Synthesis

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ChemInform Abstract: Design, Synthesis, Structure and Properties of an α-Helix Cap Template Derived from N-[(2S)-2-Chloropropionyl]-(2S)-Pro-(2R)-Ala-(2S,4S)-4-thioPro-OMe which Initiates α-Helical Structures.

ChemInform ◽

10.1002/chin.199917218 ◽

2010 ◽

Vol 30 (17) ◽

pp. no-no

Author(s):

David Gani ◽

Arwel Lewis ◽

Trevor Rutherford ◽

John Wilkie ◽

Iain Stirling ◽

...

Keyword(s):

Structure And Properties ◽

Helical Structures ◽

Design Synthesis ◽

Α Helix

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Synthesis of α-helix mimetics with four side-chains

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.06.074 ◽

2008 ◽

Vol 18 (22) ◽

pp. 5909-5911 ◽

Cited By ~ 28

Author(s):

Per Restorp ◽

Julius Rebek

Keyword(s):

Side Chains ◽

Helix Mimetics ◽

Α Helix

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Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

Angewandte Chemie International Edition ◽

10.1002/anie.200901694 ◽

2009 ◽

Vol 49 (4) ◽

pp. 736-739 ◽

Cited By ~ 84

Author(s):

Ishu Saraogi ◽

James A. Hebda ◽

Jorge Becerril ◽

Lara A. Estroff ◽

Andrew D. Miranker ◽

...

Keyword(s):

Islet Amyloid Polypeptide ◽

Islet Amyloid ◽

Helix Mimetics ◽

Α Helix

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Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

Organic & Biomolecular Chemistry ◽

10.1039/c5ob00478k ◽

2015 ◽

Vol 13 (32) ◽

pp. 8642-8646 ◽

Cited By ~ 10

Author(s):

M. E. Lanning ◽

P. T. Wilder ◽

H. Bailey ◽

B. Drennen ◽

M. Cavalier ◽

...

Keyword(s):

Helix Mimetics ◽

Α Helix ◽

Key Residues

Key residues on opposing faces of the Bak-BH3 α-helix were recapitulated by the 2,6,9-tri-substitution of a purine scaffold.

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