Mechanistic Dichotomy in the Activation of SAM by Radical SAM Enzymes: QM/MM Modeling Deciphers the Determinant

ACS Catalysis ◽  
2020 ◽  
Vol 10 (22) ◽  
pp. 13245-13250
Author(s):  
Chengxin Zhao ◽  
Yao Li ◽  
Chao Wang ◽  
Hui Chen
Keyword(s):  
Radical Sam ◽  
Radical Sam Enzymes

scholarly journals RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

2010 ◽  
Vol 132 (11) ◽  
pp. 3953-3964 ◽  
Author(s):  
Feng Yan ◽  
Jacqueline M. LaMarre ◽  
Rene Röhrich ◽  
Jochen Wiesner ◽  
Hassan Jomaa ◽  
...  
Keyword(s):  
Ribosomal Rna ◽  
Radical Sam ◽  
Radical Sam Enzymes

scholarly journals H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG

2019 ◽  
Vol 24 (6) ◽  
pp. 783-792 ◽  
Author(s):  
Amanda S. Byer ◽  
Eric M. Shepard ◽  
Michael W. Ratzloff ◽  
Jeremiah N. Betz ◽  
Paul W. King ◽  
...  
Keyword(s):  
Cluster Assembly ◽  
Radical Sam ◽  
Radical Sam Enzymes

scholarly journals Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis

2016 ◽  
Vol 52 (37) ◽  
pp. 6249-6252 ◽  
Author(s):  
Alhosna Benjdia ◽  
Alain Guillot ◽  
Benjamin Lefranc ◽  
Hubert Vaudry ◽  
Jérôme Leprince ◽  
...  
Keyword(s):  
Bond Formation ◽  
Radical Sam ◽  
Radical Sam Enzymes ◽  
Radical Sam Enzyme ◽  
Synthetic Approaches

The radical SAM enzyme AlbA has been reported to catalyze the formation of a thioether bond in the antibiotic subtilosin A. By modeling, biochemical and synthetic approaches, we propose novel mechanistic perspectives on this emerging group of enzymes.

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