CgPhen-DalPhos Enables the Nickel-Catalyzed O-Arylation of Tertiary Alcohols with (Hetero)Aryl Electrophiles

ACS Catalysis ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10878-10884
Author(s):  
Kathleen M. Morrison ◽  
Ryan T. McGuire ◽  
Michael J. Ferguson ◽  
Mark Stradiotto
Keyword(s):  
Tertiary Alcohols

Dual Roles of TBHP Enabled Regioselective Hydroetherification of (Trifluoromethyl)alkenes with Boronic Acids: Access to α-Trifluoromethyl β-Aryloxy Tertiary Alcohols

Synthesis ◽  
2021 ◽  
Author(s):  
Hengyuan Li ◽  
Chuanle Zhu
Keyword(s):  
Boronic Acids ◽  
Dual Roles ◽  
Tertiary Alcohols ◽  
High Yields

The three-starting materials four-component reaction of (trifluoromethyl)alkenes, TBHP, and boronic acids is reported, delivering various useful α-trifluoromethyl-β-aryloxy tertiary alcohols in high yields and in an exclusively regioselective hydroetherification manner. TBHP serves as both the oxidants and the nucleophiles in this reaction, as well as the O-source of the products.

Oxidation of chiral α-phenylacetate derivatives: formation of dimers with contiguous quaternary stereocenters versus tertiary alcohols

2005 ◽  
Vol 16 (21) ◽  
pp. 3599-3605 ◽  
Author(s):  
Marisa C. Kozlowski ◽  
Evan S. DiVirgilio ◽  
Krishnan Malolanarasimhan ◽  
Carol A. Mulrooney
Keyword(s):  
Tertiary Alcohols ◽  
Quaternary Stereocenters
Sign in / Sign up

Export Citation Format

Share Document