Sulfation Code and Conformational Plasticity of l-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate

2021 ◽  
Author(s):  
Chethan D. Shanthamurthy ◽  
Ana Gimeno ◽  
Shani Leviatan Ben-Arye ◽  
Nanjundaswamy Vijendra Kumar ◽  
Prashant Jain ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Biological Functions ◽  
Iduronic Acid ◽  
Conformational Plasticity

scholarly journals Investigation of the biological functions of heparan sulfate using a chemoenzymatic synthetic approach

2021 ◽  
Author(s):  
Zhangjie Wang ◽  
Katelyn Arnold ◽  
Vijay Manohar Dhurandhare ◽  
Yongmei Xu ◽  
Jian Liu
Keyword(s):  
Heparan Sulfate ◽  
Sulfated Polysaccharide ◽  
Synthetic Approach ◽  
Biological Functions ◽  
Animal Kingdom

Heparan sulfate (HS) is a highly sulfated polysaccharide playing essential physiological and pathophysiological roles in the animal kingdom.

scholarly journals Chemical synthesis of human syndecan-4 glycopeptide bearing O-, N-sulfation and multiple aspartic acids for probing impacts of the glycan chain and the core peptide on biological functions

2020 ◽  
Vol 11 (25) ◽  
pp. 6393-6404 ◽  
Author(s):  
Weizhun Yang ◽  
Yigitcan Eken ◽  
Jicheng Zhang ◽  
Logan Emerson Cole ◽  
Sherif Ramadan ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Heparan Sulfate ◽  
Biological Functions ◽  
Peptide Backbone ◽  
The Core ◽  
Glycan Chain ◽  
Core Peptide

Attaching heparan sulfate glycan on a peptide backbone can modulate biological functions of the glycan.

Synthetic heparin and heparan sulfate: probes in defining biological functions

2017 ◽  
Vol 40 ◽  
pp. 152-159 ◽  
Author(s):  
Ching-Ting Tsai ◽  
Medel Manuel L Zulueta ◽  
Shang-Cheng Hung
Keyword(s):  
Heparan Sulfate ◽  
Biological Functions

Heparanase: Structure, Biological Functions, and Inhibition by Heparin-Derived Mimetics of Heparan Sulfate

2007 ◽  
Vol 13 (20) ◽  
pp. 2057-2073 ◽  
Author(s):  
Israel Vlodavsky ◽  
Neta Ilan ◽  
Annamaria Naggi ◽  
Benito Casu
Keyword(s):  
Heparan Sulfate ◽  
Biological Functions

Toward the Solid-Phase Synthesis of Heparan Sulfate Oligosaccharides: Evaluation of Iduronic Acid and Idose Building Blocks

2013 ◽  
Vol 78 (14) ◽  
pp. 6911-6934 ◽  
Author(s):  
Nerea Guedes ◽  
Pawel Czechura ◽  
Begoña Echeverria ◽  
Ada Ruiz ◽  
Olatz Michelena ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Phase Synthesis ◽  
Iduronic Acid ◽  
Heparan Sulfate Oligosaccharides

A synthetic heparan sulfate pentasaccharide, exclusively containing l -iduronic acid, displays higher affinity for FGF-2 than its d -glucuronic acid-containing isomers

1999 ◽  
Vol 7 (8) ◽  
pp. 1567-1580 ◽  
Author(s):  
José Kovensky ◽  
Philippe Duchaussoy ◽  
Françoise Bono ◽  
Markku Salmivirta ◽  
Philippe Sizun ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Glucuronic Acid ◽  
Iduronic Acid

Heparan sulfate glycomics: towards systems biology strategies

2010 ◽  
Vol 38 (5) ◽  
pp. 1356-1360 ◽  
Author(s):  
Jeremy E. Turnbull
Keyword(s):  
Systems Biology ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Biological Functions ◽  
Combined Application ◽  
Cellular Events ◽  
Structure Activity ◽  
Future Potential ◽  
Heparan Sulfates ◽  
Molecular Code

HSs (heparan sulfates) are a complex family of cell-surface and matrix polysaccharides that have diverse biological functions, underpinned by structurally diverse patterns of backbone chain modification, especially by sulfate groups. These variant structures represent a molecular code, the ‘heparanome’, that confers the ability to interact selectively with a wide interactome of proteins, the ‘heparactome’, and thereby influence a network of cellular events. It is becoming increasingly apparent that understanding the structure–activity relationships of these enigmatic molecules requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other ‘-omics’ approaches to define the molecular code of the heparanome.

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