The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-β Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation

2020 ◽  
Vol 11 (17) ◽  
pp. 2753-2760 ◽  
Author(s):  
Joana S. Cristóvão ◽  
António J. Figueira ◽  
Ana P. Carapeto ◽  
Mário S. Rodrigues ◽  
Isabel Cardoso ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Amyloid Β ◽  
Dual Function ◽  
Zinc Chelation

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation

Metallomics ◽  
2012 ◽  
Vol 4 (9) ◽  
pp. 910 ◽  
Author(s):  
Michael R. Jones ◽  
Erin L. Service ◽  
John R. Thompson ◽  
Michael C. P. Wang ◽  
Isaac J. Kimsey ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Dual Function ◽  
Pyridine Derivatives

Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity

2020 ◽  
Vol 8 (11) ◽  
pp. 2256-2268 ◽  
Author(s):  
Xi Li ◽  
Wenjuan Wang ◽  
Xiaoyan Dong ◽  
Yan Sun
Keyword(s):  
Protein Aggregation ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Human Lysozyme ◽  
Β Protein

Conjugation of alkaline decapeptide (RTHLVFFARK) to lysozyme creates a potent multifunctional modulator (R-hLys) for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity.

scholarly journals Role of Aromatic Side Chains in Amyloid β-Protein Aggregation

2012 ◽  
Vol 3 (12) ◽  
pp. 1008-1016 ◽  
Author(s):  
Risto Cukalevski ◽  
Barry Boland ◽  
Birgitta Frohm ◽  
Eva Thulin ◽  
Dominic Walsh ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Amyloid Β ◽  
Side Chains ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Aromatic Side Chains

scholarly journals Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation

2014 ◽  
Vol 1842 (4) ◽  
pp. 646-653 ◽  
Author(s):  
Kenjiro Ono ◽  
Ryoichi Takahashi ◽  
Tokuhei Ikeda ◽  
Mineyuki Mizuguchi ◽  
Tsuyoshi Hamaguchi ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Amyloidogenic Proteins ◽  
Β Protein
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