Photocleavage from
polystyrene beads is a pivotal reaction for solid phase synthesis that relies on
photolabile linkers. The photocleavage, usually performed by batch irradiation,
suffers from incomplete and slow cleavage. To overcome these issues, continuous
flow and high-energy lamps are frequently used, but these setups are hazardous,
technically challenging, and expensive. We developed a photocleavage approach
that relies on a benchtop LED lamp and magnetic stirring. In this approach, we
crush the beads instead of keeping their integrity to increase the yield of
photocleavage. This approach proved very efficient for photocleavage of
protected oligosaccharides.
Photolabile Linkers for Solid-Phase Synthesis
