Objective:
An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo
quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction
media.
Methods:
All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and
melting points.
Results:
Various products were obtained in good to excellent yields under reaction conditions.
Conclusion:
We have efficiently developed a practical and catalyst-free approach for the synthesis of
[1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.