Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase

Biochemistry ◽  
1995 ◽  
Vol 34 (13) ◽  
pp. 4421-4427 ◽  
Author(s):  
Angela Wilks ◽  
Stephen M. Black ◽  
Walter L. Miller ◽  
Paul R. Ortiz de Montellano
Keyword(s):  
Cytochrome P450 ◽  
Fusion Protein ◽  
Heme Oxygenase ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Human Cytochrome

scholarly journals Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization

2011 ◽  
Vol 513 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Christopher C. Marohnic ◽  
Warren J. Huber III ◽  
J. Patrick Connick ◽  
James R. Reed ◽  
Karen McCammon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Human Cytochrome

Electron transfer in human cytochrome P450 reductase

2003 ◽  
Vol 31 (3) ◽  
pp. 497-501 ◽  
Author(s):  
A. Gutierrez ◽  
A. Grunau ◽  
M. Paine ◽  
A.W. Munro ◽  
C.R. Wolf ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Cytochrome P450 ◽  
Site Directed Mutagenesis ◽  
Cytochrome P450 Reductase ◽  
Cytochrome P450 Enzymes ◽  
P450 Reductase ◽  
Human Cytochrome ◽  
Redox Potentiometry ◽  
Electron Donation

Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.

scholarly journals Characterization of the Mechanism of Cytochrome P450 Reductase-Cytochrome P450-mediated Nitric Oxide and Nitrosothiol Generation from Organic Nitrates

2006 ◽  
Vol 281 (18) ◽  
pp. 12546-12554 ◽  
Author(s):  
Haitao Li ◽  
Xiaoping Liu ◽  
Hongmei Cui ◽  
Yeong-Renn Chen ◽  
Arturo J. Cardounel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cytochrome P450 ◽  
Organic Nitrates ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase

Construction ofSalmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase

2001 ◽  
Vol 38 (4) ◽  
pp. 329-338 ◽  
Author(s):  
Ken-ichi Fujita ◽  
Kazuo Nakayama ◽  
Yoshiyuki Yamazaki ◽  
Kazuhiro Tsuruma ◽  
Masami Yamada ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Reductase ◽  
Nadph Cytochrome ◽  
P450 Reductase ◽  
Human Cytochrome ◽  
Nadph Cytochrome P450 Reductase
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