Orotidine 5′-Monophosphate Decarboxylase: Transition State Stabilization from Remote Protein–Phosphodianion Interactions

Monophosphate Decarboxylase

Remarkable Rate Enhancement of Orotidine 5‘-Monophosphate Decarboxylase Is Due to Transition-State Stabilization Rather Than to Ground-State Destabilization†

Biochemistry ◽

10.1021/bi000987h ◽

2000 ◽

Vol 39 (48) ◽

pp. 14728-14738 ◽

Cited By ~ 82

Author(s):

Arieh Warshel ◽

Marek Štrajbl ◽

Jordi Villà ◽

Jan Florián

Keyword(s):

Transition State ◽

Ground State ◽

Rate Enhancement ◽

Monophosphate Decarboxylase

Dissecting the Total Transition State Stabilization Provided by Amino Acid Side Chains at Orotidine 5′-Monophosphate Decarboxylase: A Two-Part Substrate Approach†

Biochemistry ◽

10.1021/bi800939k ◽

2008 ◽

Vol 47 (30) ◽

pp. 7785-7787 ◽

Cited By ~ 27

Author(s):

Shonoi A. Barnett ◽

Tina L. Amyes ◽

Bryant M. Wood ◽

John A. Gerlt ◽

John P. Richard

Keyword(s):

Amino Acid ◽

Transition State ◽

Side Chains ◽

Amino Acid Side Chains ◽

Monophosphate Decarboxylase

Transition state stabilization by chloramphenicol acetyltransferase. Role of a water molecule bound to threonine 174.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)36884-x ◽

1993 ◽

Vol 268 (28) ◽

pp. 20997-21001

Author(s):

A Lewendon ◽

W.V. Shaw

Keyword(s):

Water Molecule ◽

Transition State ◽

Chloramphenicol Acetyltransferase ◽

Electron-Transfer-Induced Side-Chain Cleavage in Tryptophan Facilitated through Potassium-Induced Transition-State Stabilization in the Gas Phase

The Journal of Physical Chemistry A ◽

10.1021/acs.jpca.1c00690 ◽

2021 ◽

Author(s):

Filipe Ferreira da Silva ◽

Tiago Cunha ◽

Andre Rebelo ◽

Adrià Gil ◽

Maria José Calhorda ◽

...

Keyword(s):

Electron Transfer ◽

Transition State ◽

Gas Phase ◽

Side Chain ◽

Side Chain Cleavage ◽

Chain Cleavage

Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54140-5 ◽

1993 ◽

Vol 268 (1) ◽

pp. 235-240

Author(s):

S. Hasnain ◽

T. Hirama ◽

C.P. Huber ◽

P. Mason ◽

J.S. Mort

Keyword(s):

Transition State ◽

Cathepsin B ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Transition state stabilization by a phylogenetically conserved tyrosine residue in methionyl-tRNA synthetase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)47350-x ◽

1991 ◽

Vol 266 (26) ◽

pp. 17136-17141

Author(s):

G. Ghosh ◽

S. Brunie ◽

L.H. Schulman

Keyword(s):

Transition State ◽

Trna Synthetase ◽

Tyrosine Residue ◽

Methionyl Trna Synthetase ◽

Conserved Tyrosine

The Conserved Serine-Threonine-Serine Motif of the Carnitine Acyltransferases Is Involved in Carnitine Binding and Transition-State Stabilization: A Site-Directed Mutagenesis Study

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1997.7865 ◽

1997 ◽

Vol 241 (3) ◽

pp. 803-804 ◽

Cited By ~ 1

Author(s):

Ciarán N. Cronin

Keyword(s):

Transition State ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Carnitine Acyltransferases ◽

A Site ◽

Mutagenesis Study

Transition state stabilization by deaminases: Rates of nonenzymatic hydrolysis of adenosine and cytidine

Bioorganic Chemistry ◽

10.1016/0045-2068(87)90011-3 ◽

1987 ◽

Vol 15 (2) ◽

pp. 100-108 ◽

Cited By ~ 54

Author(s):

Lloyd Frick ◽

John P. Mac Neela ◽

Richard Wolfenden

Keyword(s):

Transition State ◽

Hydrolysis Of

Mutational Evidence of Transition State Stabilization by Serine 88 inEscherichia coliType I Signal Peptidase†,‡

Biochemistry ◽

10.1021/bi000301l ◽

2000 ◽

Vol 39 (24) ◽

pp. 7276-7283 ◽

Cited By ~ 21

Author(s):

Joseph L. Carlos ◽

Philip A. Klenotic ◽

Mark Paetzel ◽

Natalie C. J. Strynadka ◽

Ross E. Dalbey

Keyword(s):

Transition State ◽

Signal Peptidase ◽

RNA Catalysis and Transition State Stabilization

Nucleic Acids and Molecular Biology - Catalytic RNA ◽

10.1007/978-3-642-61202-2_22 ◽

1996 ◽

pp. 383-395 ◽

Cited By ~ 1

Author(s):

J. R. Prudent ◽

P. G. Schultz

Keyword(s):

Transition State ◽

Rna Catalysis ◽