The Ring Fragmentation Product of Thymidine C5-Hydrate When Present in DNA Is Repaired by theEscherichia coliFpg and Nth Proteins†

Biochemistry ◽  
1998 ◽  
Vol 37 (21) ◽  
pp. 7757-7763 ◽  
Author(s):  
Juan Jurado ◽  
Murat Saparbaev ◽  
Tracy J. Matray ◽  
Marc M. Greenberg ◽  
Jacques Laval
Keyword(s):  
Fragmentation Product

REARRANGEMENT STUDIES WITH 14C: XXI. SIDE CHAIN REARRANGEMENT AND FRAGMENTATION FOLLOWING FRIEDEL–CRAFTS ALKYLATION OF BENZENE WITH β-14C-ETHYL IODIDE

1964 ◽  
Vol 42 (8) ◽  
pp. 1771-1777
Author(s):  
C. C. Lee ◽  
M. C. Hamblin ◽  
J. F. Uthe
Keyword(s):  
Reaction Time ◽  
Aluminum Chloride ◽  
Specific Activity ◽  
Ethyl Iodide ◽  
Isotopic Dilution ◽  
Side Chain ◽  
Initial Formation ◽  
Fragmentation Product ◽  
Alkylation Of Benzene ◽  
Higher Temperature

The aluminum chloride catalyzed reaction between β-14C-ethyl iodide and benzene in 1,2,4-trichlorobenzene as solvent was studied under different conditions of temperature and reaction time. Yields of ethylbenzene were estimated by isotopic dilution. Up to 20% rearranged product, α-14C-ethylbenzene, was found. The trend indicated that yield of ethylbenzene was lower and side chain rearrangement greater when the reaction mixture was heated at higher temperature for longer time. The rearrangement apparently occurred after the initial formation of β-14C-ethylbenzene. After a reaction time of 5 min at 154 °C, only 0.1–0.3% unreacted and unrearranged β-14C-ethyl iodide was recovered while the ethylbenzene obtained from the reaction showed about 2% rearrangement. When β-14C-ethylbenzene was heated with aluminum chloride in 1,2,4-trichlorobenzene for 2 or 24 h, rearrangement to α-14C-ethylbenzene was observed. In some experiments, a fragmentation product, toluene, was isolated. Its specific activity suggested that 1 mole of active ethylbenzene gave 2 moles of toluene only one of which was active. The mechanistic implications of these findings are discussed.

Amidinato and triazenido complexes of ruthenium(II): X-ray crystal structure of the N,N′-diphenylformamidine fragmentation product [RuCl(NH2Ph){PhNC(H)NPh}(Me2SO)2]

Polyhedron ◽  
2001 ◽  
Vol 20 (15-16) ◽  
pp. 1875-1880 ◽  
Author(s):  
Terry Clark ◽  
James Cochrane ◽  
Stephen F. Colson ◽  
Kausar Z. Malik ◽  
Stephen D. Robinson ◽  
...  
Keyword(s):  
Crystal Structure ◽  
X Ray ◽  
Fragmentation Product

scholarly journals In situ measurement of the particle size distribution of the fragmentation product of laser-shock-melted aluminum using in-line picosecond holography

AIP Advances ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 025208 ◽  
Author(s):  
Ying-Hua Li ◽  
Yu Zhao ◽  
Xue-Mei Li ◽  
Zu-Gen Zhang ◽  
Xiang-Ping Ye ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
In Situ Measurement ◽  
Laser Shock ◽  
Fragmentation Product

scholarly journals The effects of the ring fragmentation product of thymidine C5-hydrate on phosphodiestrases and klenow (exo-)fragment

1995 ◽  
Vol 23 (22) ◽  
pp. 4642-4648 ◽  
Author(s):  
Tracy J. Matray ◽  
karin J. Haxton ◽  
Marc M. Greenberg
Keyword(s):  
Fragmentation Product

AlkA Protein Is the ThirdEscherichia coliDNA Repair Protein Excising a Ring Fragmentation Product of Thymine†

Biochemistry ◽  
2000 ◽  
Vol 39 (46) ◽  
pp. 14263-14268 ◽  
Author(s):  
Cyril V. Privezentzev ◽  
Murat Saparbaev ◽  
Aruna Sambandam ◽  
Marc M. Greenberg ◽  
Jacques Laval
Keyword(s):  
Fragmentation Product ◽  
Repair Protein

Expedient synthesis of unsaturated amide alkaloids from Piper spp: Exploring the scope of recent methodology

1996 ◽  
Vol 74 (3) ◽  
pp. 419-432 ◽  
Author(s):  
George M. Strunz ◽  
Heather J. Finlay
Keyword(s):  
Key Words ◽  
Cyclic Ketone ◽  
Fragmentation Product ◽  
Aryl Aldehyde ◽  
Grob Fragmentation ◽  
Redox Isomerization

The Sakai aryl aldehyde – cyclic ketone aldol – Grob fragmentation sequence was extended to cinnamaldehyde and cyclohexanone, and the product was elaborated to analogues of the alkaloid piperstachine. The effects of substituents on the reaction involving cinnamaldehyde were studied. The aldol-fragmentation sequence failed with benzaldehyde when cyclooctanone or cyclobutanone was substituted for cyclohexanone or cyclopentanone, and the reasons for this failure were examined. Four-carbon Wittig homologation of the piperonal–cyclobutanone aldol-fragmentation product, a hypothetical route to alkaloids such as retrofractamide A, was thus not viable. Instead, three-carbon homologation of the readily available piperonal–cyclopentanone product, using alkyne chemistry recently disclosed by Lu and Trost, afforded these alkaloids in excellent overall yield. The alkyne isomerization was also used to effect efficient syntheses of pellitorine and several other non-aromatic 2E,4E-dienoic Piper amide alkaloids. Key words: Piper, amides, alkaloids, insecticides, aldol, fragmentation, cinnamaldehydes, alkyne, redox, isomerization.

Ion-molecule reactions of formic acid. II. Rearrangement reactions

1978 ◽  
Vol 31 (12) ◽  
pp. 2593 ◽  
Author(s):  
CG Freeman ◽  
PW Harland ◽  
MJ McEwan
Keyword(s):  
Charge Transfer ◽  
Formic Acid ◽  
General Equation ◽  
Rate Coefficients ◽  
Fragmentation Product ◽  
Ion Molecule Reactions ◽  
Positive Ions ◽  
Rearrangement Reactions

Rate coefficients for a number of rearrangement reactions of positive ions with HCOOH are reported. These reactions may be represented by the general equation �������������������������� Y+ + HCOOH → products Most reactant ions resulted in the fragmentation product HCO+ and five reactant ions, N+, O+, CN+, N2+ and CO+, were observed to have rate coefficients much greater than predicted by the ADO model. An explanation for the high rates observed for these reactant ions is proposed and involves dissociative charge transfer by a non-orbiting electron-jump mechanism.

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