Regulation of Recombinant Monoclonal Antibody Production in Chinese Hamster Ovary Cells: A Comparative Study of Gene Copy Number, mRNA Level, and Protein Expression

2006 ◽  
Vol 22 (1) ◽  
pp. 313-318 ◽  
Author(s):  
Z. Jiang ◽  
Y. Huang ◽  
S.T. Sharfstein
Keyword(s):  
Monoclonal Antibody ◽  
Copy Number ◽  
Chinese Hamster Ovary Cells ◽  
Mrna Level ◽  
Chinese Hamster ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Monoclonal Antibody Production ◽  
Ovary Cells ◽  
Recombinant Monoclonal Antibody

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

2011 ◽  
Vol 27 (6) ◽  
pp. 1689-1699 ◽  
Author(s):  
Sarah L. Davies ◽  
Peter M. O'Callaghan ◽  
Jane McLeod ◽  
Leon P. Pybus ◽  
Yun Hee Sung ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Production ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Gene Vector ◽  
Monoclonal Antibody Production ◽  
Ovary Cells ◽  
Recombinant Monoclonal Antibody

Optimization of chemically defined feed media for monoclonal antibody production in Chinese hamster ovary cells

2015 ◽  
Vol 120 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Shohei Kishishita ◽  
Satoshi Katayama ◽  
Kunihiko Kodaira ◽  
Yoshinori Takagi ◽  
Hiroki Matsuda ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Production ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Monoclonal Antibody Production ◽  
Ovary Cells

Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

2013 ◽  
Vol 111 (2) ◽  
pp. 372-385 ◽  
Author(s):  
Leon P. Pybus ◽  
Greg Dean ◽  
Nathan R. West ◽  
Andrew Smith ◽  
Olalekan Daramola ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Production ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Monoclonal Antibody Production ◽  
Ovary Cells
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