Chemical Genomics: Dialed in Transcriptional Network Control with Non-steroidal Glucocorticoid Receptor Modulators

2006 ◽  
Vol 1 (3) ◽  
pp. 139-140 ◽  
Author(s):  
Jasmina J. Allen ◽  
Kevan M. Shokat
Keyword(s):  
Glucocorticoid Receptor ◽  
Transcriptional Network ◽  
Network Control ◽  
Chemical Genomics ◽  
Receptor Modulators

Next generation glucocorticoid receptor modulators

2018 ◽  
Author(s):  
Karl Edman ◽  
Graham Belfield ◽  
Matthew Dearman ◽  
Goran Edenro ◽  
Stefan Geschwindner ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Next Generation ◽  
Receptor Modulators

scholarly journals Selective Glucocorticoid Receptor Modulators: Future of Glucocorticoid Immunosuppressive Therapy?

Endocrinology ◽  
2011 ◽  
Vol 152 (8) ◽  
pp. 2927-2929 ◽  
Author(s):  
R. A. M. Quax ◽  
R. P. Peeters ◽  
R. A. Feelders
Keyword(s):  
Glucocorticoid Receptor ◽  
Immunosuppressive Therapy ◽  
Receptor Modulators

Antidiabetic Activity of Passive Nonsteroidal Glucocorticoid Receptor Modulators

2005 ◽  
Vol 48 (16) ◽  
pp. 5295-5304 ◽  
Author(s):  
J. T. Link ◽  
Bryan Sorensen ◽  
Jyoti Patel ◽  
Marlena Grynfarb ◽  
Annika Goos-Nilsson ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Antidiabetic Activity ◽  
Receptor Modulators

Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators

2009 ◽  
Vol 19 (8) ◽  
pp. 2139-2143 ◽  
Author(s):  
Bingwei V. Yang ◽  
Wayne Vaccaro ◽  
Arthur M. Doweyko ◽  
Lidia M. Doweyko ◽  
Tram Huynh ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulators

Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series†

2006 ◽  
Vol 49 (14) ◽  
pp. 4216-4231 ◽  
Author(s):  
Mike Barker ◽  
Margaret Clackers ◽  
Royston Copley ◽  
Derek A. Demaine ◽  
Davina Humphreys ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulators ◽  
Agonist Trigger

Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators†

2010 ◽  
Vol 53 (3) ◽  
pp. 1270-1280 ◽  
Author(s):  
Hai-Yun Xiao ◽  
Dauh-Rurng Wu ◽  
Mary F. Malley ◽  
Jack Z. Gougoutas ◽  
Sium F. Habte ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Novel Synthesis ◽  
Receptor Modulators

scholarly journals Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

2009 ◽  
Vol 106 (12) ◽  
pp. 4929-4934 ◽  
Author(s):  
A. N. Gerber ◽  
K. Masuno ◽  
M. I. Diamond
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulators

Glucocorticoid-based therapeutic options for PTSD

2016 ◽  
Vol 33 (S1) ◽  
pp. S215-S215
Author(s):  
S. Ouanes
Keyword(s):  
Systematic Review ◽  
Glucocorticoid Receptor ◽  
Glucocorticoid Receptors ◽  
Traumatic Event ◽  
Therapeutic Options ◽  
Curative Treatment ◽  
Ptsd Symptoms ◽  
Preventive Interventions ◽  
Competing Interest ◽  
Receptor Modulators

IntroductionPTSD has been associated with HPA axis alterations, mainly consisting of reduced cortisol levels, elevated CRH and enhanced glucocorticoid receptor responsiveness. These findings led to the emergence of glucocorticoid-based therapeutic options for PTSD.ObjectiveTo outline the different glucocorticoid-based interventions for PTSD either for prophylactic or for curative treatment.MethodsA systematic review was performed. The Medline database was searched using the following keywords: ‘PTSD’, ‘treatment’, ‘Glucocorticoids’, ‘hydrocortisone’.ResultsGlucocorticoid-based therapeutic for PTSD comprise preventive and curative interventions. Preventive interventions mainly consist of administering one single bolus of hydrocortisone shortly following the exposure to a traumatic event. Evidence comes from six published trials, all positive. Curative interventions include: prescribing hydrocortisone over short periods of time to treat PTSD symptoms, using Glucocorticoids to augment psychotherapy (in particular exposure therapy) for PTSD and using Mifepristone, a glucocorticoid receptor antagonist. Moreover, novel glucocorticoid receptor modulators are currently being developed and tested on animal models as a potential curative treatment for PTSD.ConclusionsUse of hydrocortisone in preventing PTSD might be tempting, as is the use of hydrocortisone or Glucocorticoid receptors antagonists/modulators in treating PTSD. Yet, it should be emphasized that these interventions are not mainstream yet. They rather reflect a revolutionary new direction.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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