Phytochrome models. 11. Photophysics and photochemistry of phycocyanobilin dimethyl ester

1991 ◽  
Vol 113 (19) ◽  
pp. 7322-7334 ◽  
Author(s):  
Silvia E. Braslavsky ◽  
Dagmar Schneider ◽  
Klaus Heihoff ◽  
Santiago Nonell ◽  
Pedro F. Aramendia ◽  
...  
Keyword(s):  
Dimethyl Ester ◽  
Phytochrome Models

ChemInform Abstract: Phytochrome Models. Part 11. Photophysics and Photochemistry of Phycocyanobilin Dimethyl Ester.

ChemInform ◽  
2010 ◽  
Vol 22 (51) ◽  
pp. no-no
Author(s):  
S. E. BRASLAVSKY ◽  
D. SCHNEIDER ◽  
K. HEIHOFF ◽  
S. NONELL ◽  
P. F. ARAMENDIA ◽  
...  
Keyword(s):  
Dimethyl Ester ◽  
Phytochrome Models

PHYTOCHROME MODELS: PART 10. CONCENTRATION, SONICATION AND TEMPERATURE AFFECTING THE POPULATION OF THE GROUND-STATE CONFORMERS OF BILIVERDIN DIMETHYL ESTER IN SOLUTION

1986 ◽  
Vol 44 (4) ◽  
pp. 433-440 ◽  
Author(s):  
Hussain Al-Ekabi ◽  
Inga-Mai Tegmo-Larson ◽  
Silvia E. Braslavsky ◽  
Alfred R. Holzwarth ◽  
Kurt Schaffner
Keyword(s):  
Ground State ◽  
Dimethyl Ester ◽  
Phytochrome Models

ChemInform Abstract: PHYTOCHROME MODELS, II. THE FLUORESCENCE OF BILIVERDIN DIMETHYL ESTER

1979 ◽  
Vol 10 (13) ◽  
Author(s):  
A. R. HOLZWARTH ◽  
H. LEHNER ◽  
S. E. BRASLAVSKY ◽  
K. SCHAFFNER
Keyword(s):  
Dimethyl Ester ◽  
Phytochrome Models

Phytochrome models. 6. Conformation control by membrane of biliverdin dimethyl ester incorporated into lipid vesicles

1981 ◽  
Vol 103 (24) ◽  
pp. 7152-7158 ◽  
Author(s):  
Inga Mai Tegmo-Larsson ◽  
Silvia E. Braslavsky ◽  
Stephen Culshaw ◽  
Raymond M. Ellul ◽  
Claude Nicolau ◽  
...  
Keyword(s):  
Dimethyl Ester ◽  
Lipid Vesicles ◽  
Phytochrome Models

ChemInform Abstract: PHYTOCHROME MODELS. 6. CONFORMATION CONTROL BY MEMBRANE OF BILIVERDIN DIMETHYL ESTER INCORPORATED INTO LIPID VESICLES

1982 ◽  
Vol 13 (11) ◽  
Author(s):  
I. M. TEGMO-LARSSON ◽  
S. E. BRASLAVSKY ◽  
S. CULSHAW ◽  
R. M. ELLUL ◽  
C. NICOLAU ◽  
...  
Keyword(s):  
Dimethyl Ester ◽  
Lipid Vesicles ◽  
Phytochrome Models

Phytochrome Models, I. Isolation, Characterization, and Solution Conformation of Biliverdin Dimethyl Ester and Its XIIIα Isomer

1978 ◽  
Vol 1978 (12) ◽  
pp. 1990-2001 ◽  
Author(s):  
Harold Lehner ◽  
Silvia E. Braslavsky ◽  
Kurt Schaffner
Keyword(s):  
Dimethyl Ester ◽  
Solution Conformation ◽  
Phytochrome Models

(±)-3,5-Bis(substitutedmethyl)pyrrolidines: Application to the Synthesis of Analogues of glycine-L-proline-L-glutamic Acid (GPE)

2018 ◽  
Vol 15 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Joana Ferreira da Costa ◽  
Xerardo Garcia-Mera ◽  
David Silva Poceiro ◽  
Olga Caamano
Keyword(s):  
Therapeutic Strategy ◽  
Dimethyl Ester ◽  
Neuronal Loss ◽  
New Drugs ◽  
Ester Hydrochloride ◽  
1H And 13C Nmr ◽  
Survival Factor ◽  
Synthetic Strategy ◽  
Β Amyloid ◽  
Structural Simplicity

Backiground: Alzheimer's disease is a fatal, complex, neurodegenerative disease over 46 million people live with dementia in the world characterized by the presence of plaques containing β-amyloid and neuronal loss. The GPE acts as a survival factor against β-amyloid insult in brain and suggests a possible new therapeutic strategy for the treatment of Central Nervous System injuries and neurodegenerative disorders. The structural simplicity of GPE makes it a suitable lead molecule for the development of new drugs that to cross the blood-brain barrier. Objective: With these aims in mind, we embarked on a synthetic program focused on the modification of the Lproline residue of GPE in order to investigate its importance on the neuroprotective activities. Method: The general synthetic strategy involved the preparation of several modified proline residues, which were subsequently coupled to N-Boc-glycine-OH and glutamic dimethyl ester hydrochloride. Results: the mixture of compounds 11 was obtained in good yields (72%) under these conditions, and this was readily separated by column chromatography and the components were identified by 1H and 13C NMR spectral, as well as by its EI HRMS. Conclusion: Compound (±)-8 was coupled with L-glutamic dimethyl ester hydrochloride gave a mixture of dipeptides 9a and 9b in a satisfactory yield. The use of T3P as coupling agent of the mixture 10a and 10b with Boc-glycine provided a new analogue of GPE, tripeptide 11, obtained with an overall yield of 65% from (±)-1.

ChemInform Abstract: PORPHYRINS. VIII. MESO-FORMYLATION OF METAL COMPLEXES OF THE DIMETHYL ESTER OF MESOPORPHYRIN IX

1979 ◽  
Vol 10 (8) ◽  
Author(s):  
G. V. KIRILLOVA ◽  
T. A. BABUSHKINA ◽  
V. P. SUBOCH ◽  
G. V. PONOMAREV
Keyword(s):  
Metal Complexes ◽  
Dimethyl Ester

ChemInform Abstract: A CONVENIENT AND RAPID SYNTHESIS OF MESOHEMIN IX DIMETHYL ESTER CHLORIDE

1980 ◽  
Vol 11 (35) ◽  
Author(s):  
M. A. PHILLIPPI ◽  
H. M. GOFF
Keyword(s):  
Dimethyl Ester ◽  
Rapid Synthesis
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