scholarly journals Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry

2019 ◽  
Vol 141 (26) ◽  
pp. 10431-10439 ◽  
Author(s):  
Joseph W. Schafer ◽  
Ioanna Zoi ◽  
Dimitri Antoniou ◽  
Steven D. Schwartz
Keyword(s):  
Directed Evolution ◽  
Protein Dynamics ◽  
Artificial Enzymes

Artificial Enzymes bringing together Computational Design and Directed Evolution

2021 ◽  
Author(s):  
Beatriz de Pina Mariz ◽  
Sara S Carvalho ◽  
Iris Batalha ◽  
Ana Sofia Pina
Keyword(s):  
Directed Evolution ◽  
Chemical Reactions ◽  
Computational Design ◽  
Industrial Processes ◽  
Artificial Enzymes ◽  
Ancient Times

Enzymes are proteins that catalyse chemical reactions and, as such, have been widely used to facilitate a variety of natural and industrial processes, dating back to ancient times. In fact,...

scholarly journals Computational Enzyme Design: Refining Artificial Enzymes and Exploring Paths of Directed Evolution

2011 ◽  
Vol 100 (3) ◽  
pp. 219a
Author(s):  
Maria P. Frushicheva ◽  
Arieh Warshel
Keyword(s):  
Directed Evolution ◽  
Artificial Enzymes ◽  
Enzyme Design ◽  
Computational Enzyme Design

scholarly journals Rationalizing Directed Evolution through Protein Dynamics

2014 ◽  
Vol 106 (2) ◽  
pp. 654a
Author(s):  
Saurabh Belsare
Keyword(s):  
Directed Evolution ◽  
Protein Dynamics

Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers

2015 ◽  
Vol 10 (10) ◽  
pp. 1625-1642 ◽  
Author(s):  
Alexander I Taylor ◽  
Philipp Holliger
Keyword(s):  
Directed Evolution ◽  
Artificial Enzymes

Analysis of Actin Protein Dynamics at the Protrusion Process of Cell Movement

2014 ◽  
Vol 134 (2) ◽  
pp. 177-182
Author(s):  
Takuya Miura ◽  
Michiko Sugawara ◽  
Tohru Yagi ◽  
Ken-ichi Tsubota ◽  
Hao Liu
Keyword(s):  
Protein Dynamics ◽  
Cell Movement ◽  
Actin Protein

Fe-N-C Artificial Enzyme: Activation of Oxygen for Dehydrogenation and Monoxygenation of Organic Substrates under Mild Condition and Cancer Therapeutic Application

2018 ◽  
Author(s):  
Fei He ◽  
Li Mi ◽  
Yanfei Shen ◽  
Toshiyuki Mori ◽  
Songqin Liu ◽  
...  
Keyword(s):  
Mild Condition ◽  
Enzyme Activation ◽  
Artificial Enzymes ◽  
Organic Substrates ◽  
Artificial Enzyme ◽  
Therapeutic Application ◽  
Highly Efficient ◽  
Activation Of Oxygen

Developing highly efficient artificial enzymes that directly employ O<sub>2</sub> as terminal oxidant has long been pursued but has rarely achieved yet. We report Fe-N-C has unusual enzyme-like activity in both dehydrogenation and monoxygenation of organic substrates with ~100% selectivity by direct using O<sub>2</sub>.

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