scholarly journals High Mass Analysis with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: From Inorganic Salt Clusters to Antibody Conjugates and Beyond

2020 ◽  
Vol 31 (5) ◽  
pp. 1155-1162 ◽  
Author(s):  
Iain D. G. Campuzano ◽  
Michael Nshanian ◽  
Christopher Spahr ◽  
Carter Lantz ◽  
Chawita Netirojjanakul ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Inorganic Salt ◽  
High Mass ◽  
Ion Cyclotron Resonance ◽  
Mass Analysis ◽  
Ion Cyclotron ◽  
Antibody Conjugates

scholarly journals Identification of Human Serum Peptides in Fourier Transform Ion Cyclotron Resonance Precision Profiles

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Simone Nicolardi ◽  
Hans Dalebout ◽  
Marco R. Bladergroen ◽  
Wilma E. Mesker ◽  
Rob A. E. M. Tollenaar ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Human Serum ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Biomarker Discovery ◽  
High Mass ◽  
Ion Cyclotron Resonance ◽  
Ultrahigh Resolution ◽  
Peptide Profile ◽  
Ion Cyclotron

The continuous efforts to find new prognostic or diagnostic biomarkers have stimulated the use of mass spectrometry (MS) profiles in a clinical setting. In the early days (about one decade ago), a single low-resolution mass spectrum derived from an individual’s body fluid was used for comparative studies. However, a peptide profile of a complex mixture is most informative when recorded on an ultrahigh resolution instrument such as a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. In this study we show the benefits of the ultrahigh resolving power and the high mass accuracy and precision provided by an FTICR mass spectrometer equipped with a 15-tesla magnet. The ultrahigh-resolution data not only allow assignment of fragment ions with high charge states (4+, 5+) but also enhance confidence of human serum peptide identifications from tandem MS experiments. This is exemplified with collision-induced dissociation (CID) and electron transfer dissociation (ETD) data of middle-down-sized endogenous or protein-breakdown peptides that are of interest in biomarker discovery studies.

5.6 tesla Fourier transform ion cyclotron resonance mass spectrometer for analysis of volatile complex mixtures

1998 ◽  
Vol 69 (6) ◽  
pp. 2278-2284 ◽  
Author(s):  
Ryan P. Rodgers ◽  
Forest M. White ◽  
Daniel G. McIntosh ◽  
Alan G. Marshall
Keyword(s):  
Fourier Transform ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Complex Mixtures ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron
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